| Background:Serum lipid is the cornerstones of clinical risk stratification ofprediction for atherosclerotic diseases. Low density lipoprotein (LDL) is considered tobe the major atherogenic class, and high density lipoprotein (HDL) is considered to bethe main lipoprotein particles of anti-atherogenic class. In clinical practice, the amountof LDL and HDL is estimated by measuring concentration of their cholesterols. Largescale clinical trials show that LDL-C and HDL-C is one of the important risk factors ofcerebral atherosclerosis, LDL-C increased and HDL-C decreased in ischemic strokecaused by atherosclerosis has a direct relationship. LDL-C and HDL-C ratio is a strongpredictor of clinical prediction of vascular events. Apolipoprotein B（apoB） is not onlya major protein of LDL particles, but almost all of the atherogenic particle surfacecontains a unit of apoB. Oxidized apoB release a variety of inflammatory products andthese inflammatory products spread in the atherosclerosis arterial wall, cause theprogression of atherosclerosis, whereas apolipoprotein A1（apoA1）is the major proteincomponent of high density lipoprotein, play a key role in the process of cholesterol fromperipheral tissues to be transported to the liver and surrounding tissues in reversecholesterol transport(RCT). ApoA1in occurrence also has antioxidant,antiinflammatory, protect endothelial function, thrombosis, inhibit the occurrence anddevelopment of atherosclerosis and other roles.The ratio of apoB/apoA1reflects thebalance between the atherogenic particles and the particles of anti-atherosclerosis.Forcerebral atherosclerosis, whether apoB, apoA1and the ratio of apoB/apoA1withLDL-C、HDL-C、the ratio of LDL-C/HDL-C have the same prediction value is worthstudying.Objective:To study the cerebral vascular stenosis patients and without cerebralartery stenosis patients with apoB, apoA1, low density lipoprotein cholesterol（LDL-C),high density lipoprotein cholesterol (HDL-C), and calculate the apoB/apoA1ratio, LDL-C/HDL-C ratio. Evaluation of intracranial artery stenosis group, extracranialartery stenosis group and mixed with intracranial and extracranial artery stenosis groupcompared to without cerebrovascular stenosis group the apoB, apoA1, LDL-C, HDL-C,apoB/apoA1and LDL-C/HDL-C，to see whether there are differences and thedifferences have statistically significant. Evaluation of intracranial artery stenosis group,extracranial artery stenosis group and mixed with intracranial and extracranial arterystenosis group apoB, apoA1, LDL-C, HDL-C, apoB/apoA1and LDL-C/HDL-C,to seewhether there are differences among them.Research methods:The experimental group selectes severe cerebral artery stenosis(90%and above) or occlusion patients from2011March to2012March in Carotidsurgery of Dalian Central Hospital.The experimental group was divided into threegroups:intracranial artery stenosis group, extracranial artery stenosis group (neck) andmixed of intracranial and extracranial artery stenosis. Control group selects the peoplewho hospitalized in this hospital in the period of the same time without cerebralvascular stenosis.The experimental group selection criteria: head and neck CTA displayfor the patients with severe stenosis(90%and above) or occlusion, control groupinclusion criteria: patients without cerebral vascular stenosis as control group.Exclusioncriteria: The function of liver and kidney are damaged, cancer, infectious diseases,autoimmune diseases, familial dyslipidemia, the people who past (2months) taken orare taking lipid-lowering drugs, because the accuracy of biochemical indicators will beaffected by the related factors so they are exceptd. Each group has sixty persons.Thedifferences of age, sex, smoking, drinking, hypertension history, diabetes history、heartdisease history and family history between the experimental group and the controlgroup do not have statistically significant.Entry the experimental groups and control group were240cases of patients withgeneral information and the second morning fasting apoA1, apoB, LDL-C and HDL-Cbiochemical index, calculation apoB/apoA1and LDL-C/HDL-C. Statistical analysisusing SPSS11.5software.Results:1.The experimental groups compared with the control group: intracranialartery stenosis group, extracranial artery stenosis and mixed group of intracranial andextracranial artery stenosis apoA1, HDL-C values were lower than that in control group(P<0.05), while apoB, LDL-C, apoB/apoA1, LDL-C/HDL-C values were higher thancontrol group (P<0.05);2.Comparison either two of the experimental groups: extracranial artery stenosis and mixed group of intracranial and extracranial artery stenosis:apoA1、HDL-C valuewere decreased (P<0.05) compare with intracranial artery stenosis group, while apoB,LDL-C, apoB/apoA1, LDL-C/HDL-C values were compared with intracranial arterystenosis group increased (P<0.05); extracranial artery stenosis and extracranial andintracranial mixed artery stenosis group apoA1, HDL-C, apoB, LDL-C, apoB/apoA1,LDL-C/HDL-C values donot have statistically significant (P>0.05).Conclusion:1.ApoB, apoA1, apoB/apoA1and LDL-C, HDL-C, LDL-C/HDL-Cchanges in patients with cerebral vascular atherosclerosis is consistent. Therefore, apoB,apoA1, apoB/apoA1are also associated with cerebral atherosclerosis.2.LDL-C, apoB, apoB/apoA1, LDL-C/HDL-C increased, apoA1, HDL-Cdecreased may be more associated with extracranial vascular atherosclerosis.. |
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