Influence Of Innervations And Bone Integration By Changing The Protocols Of Implant Treatment

Objective: To unravellthe influence of distribution of myelinated nerve fibers inperi-implant bone tissue by changing the implant treatment protocols. Besides, a novel3D-approach will be proposed to investigate the peri-implant trabecular structures bymeans of cone beam computed tomography (CBCT).Materials and Methods: The bilateral3rdand4thmandibular premolar besides the3rdmaxillary incisor were extracted from six dogs. Then the dogs randomly received oneout of3treatment protocols: normal extraction socket healing (serving as control);immediate implant placement and immediate loading (IIP+IL); delayed implantplacement and delayed loading (DIP+DL). After2months, the dogs were sacrificed,and specimens were prepared for CBCT scanning and histological observation.Result:CBCT data analysis showed, IIP+IL and DIP+DL had a significantly highervalue than the control for bone surface volume ratio (BS/BV).Histological observation showed there were nerve endings surrounding the implants inIIP, IL, DIP and DL groups, adjacent to the screw thread and the bottom of the implants.More myelinated nerve fibers were found in the peri-implant tissue of the immediateloading group when compared with the delayed loading group.Conclusion:The present results suggest that occlusal force may cause an increasednumber of regenerated nerve fibers. The immediate implant placement and loadingprotocol may have an improved bone structural integration compared to that obtainedby normal extraction healing.