Effect Of Onion’s Extraction On Colorectal Cancer With Hyperlipidemia

[Objectives] The aim of this study is to investigate the effect of onion’s extraction on colorectal cancer with hyperlipidemia.[Method] we established a hyperlipidemia colon tumor model involving subcutaneous colon translocation and orthotopic transplantation, through giving the high-fat die, then administrated onion’s extraction.. capecitabine and simvastatin. We found out the impaction of the onion’s extraction to the hyperlipidemia colon tumor by observing the changes in tumor growth and lipids.[Results] The nude mice’s(high-fat diet by gavage) TC、HDL、apoA、TG、LDL、Lpa、apoB increased, but only the TC、HDL、apoA showed statistically significant compared mith the normal diet group; From the tumor growth curve, the tumor grew fastest in the high-fat diet group G2(without drug) and had statistically significant compared with the other groups except group G4; The tumor growth rate of high-fat diet group G4(only used simvastatin) was lower than group G2, but highter than group G1、G3、G4、G5、G6、G7、 showed statistically significant except G6、G7; The tumor of the normal diet group G1(only used capecitabine) grew slower than group G6and G7,but faster than G3、G5、G8, there were no statistically significant; The tumor of high fat diet group G5(used capecitabine combine simvastatin) grew slowest and slightly lower than G8(used high-dose of onion’s extraction) and G3(only used capecitabine), the difference had no statistically significant, but showed statistically significant compared with G6(used low-dose of onion’s extraction)、G7(used medium-dose of onion’s extraction); There were no statistically significant between the three groups(used onion’s extraction), the tumor of G6grew fastest but slowest in G8. The changes of the tumor growth rate were consistent with the changes of the tumor volume. on the third week, the TG and LPa significantly decreased in all groups; the LDL increased in G1、G2、G3(without simvastatin), but decreased while using simvastatin and onion’s extraction; the TC、HDL、 apoB decreased significant in the groups (used onion’s extraction) compared with high-fat diet group; on the fifth week, the TG increased in G2、G3、 G4, and showed statistically significant.[Conclusion] Our study established a hyperlipidemia colon tumor model involving subcutaneous colon translocation and orthotopic transplantation, this model was an ideal research model for mutual influence of hyperlipidemia and colorectal cancer. We found that the simvastatin did not inhibit the proliferation of colorectal cancer significantly, it could not enhance the effection of capecitabine inhibited colorectal cancer grow, but hyperlipidemia tumor’s reaction to capecitabine was better than normal diet, the reason needs to be further research. In the early process of tumor proliferation, serum TG might be consumed as a nutrient. With the tumor grew continued, the TG might increase gradually, but this result needs to be further study in the condition of excluding the influence of high-fat diet; and we did not find that serum triglycerides elevated after administration of capecitabine. The onion’s extraction could inhibit the proliferation of colorectal cancer, the function of the high-dose of onion’s extraction was fairly to capecitabine, which provided a new direction in protecting and treating colorectal cancer; the onion’s extraction could decrease TC、apoB and LDL, which played to reduce the LDL and TC mainly by decreasing the apoB.