Retrospective Analysis Of Variation Of Pathogens Distribution And Antimicrobial Resistance In Children With Urinary Tract Infection In Chongqing

Objective：To investigate the variation of pathogens distribution andantimicrobial resistance in children with UTI in recent3years to guideclinical treatmentMethods：The clinical data of533cases of children with UTI whichcame from Children’s Hospital of Chongqing Medical University from2009to2012were reviewed and the clinical features were analyzed．Result：（1）Only25.1%patients had the urinary tract irritation.（2）UTI in children is often associated with renal disease or urinarytract malformations complexity factors，up to62.3%, Medical diseases(such as nephrotic syndrome and nephritis) accounted for approximately28.0%, Surgical diseases(such as hydronephrosis, VUR,UPJO and othermalformations) accounted for about34.3%.(3) A total of521pathogenic bacteria were determined from533urine specimens, Gram-negative bacteria accounted for71.0%, accounted for25.1%of Gram-positive bacteria, fungi accounted for3.4%.Compared with four years ago, the G-bacteria showed a downward trendand upward trend G+bacteria, while fungi had no significant change.(4) Common Gram-negative bacteria to carbapenems, quinolones,and a small part of penicillins added enzyme stabilizers（piperacillin/tazobactam) have less resistance, while most of the penicillins，third-generation and fourth-generation cephalosporins, almost all first-generation and second-generation cephalosporins Resistance rates werehigh.Common Gram-positive cocci to vancomycin class and theoxazolidinone antibiotic resistance are low， to penicillins (exceptEnterococcus faecalis), cephalosporins and macrolide resistance rateshigh.（5）Antibiotic resistance to quinolones, carbapenems and sulfa ofSome pathogens has decreased, while the more commonly usedantibiotics such as cephalosporins resistance is still high.Conclusion：（1）Urinary tract infections in children due to its atypical clinicalmanifestations, clinical easily cause misdiagnosis.（2）Urinary tract infections in children are often associated withurinary tract congenital malformations and other complex factors.（3）In recent5years, the distribution of pathogens has changedin Chongqing，which the G-bacteria showed a downward trend and G+ bacteria showed a upward trend.（4）The pathogenic bacteria resistance to Antibiotics has alsochanged in recent5years of Chongqing. The observation of variation ofpathogenic bacteria and drug resistance is of great importance．...