The Significances Of RET Fusion Gene In Non-small Cell Lung Cancer

Lung cancer is the leading cause of cancer-related death worldwide. Moleculartarget therapy has become a hot research direction of NSCLC（non-small cell lungcancer, NSCLC） treatment. RET fusion gene is present in some subsets of lungcancer, and the mutually exclusive nature of the RET fusions and other oncogenicalterations such as EGFR, K-rsa, ALK,etc. The mutations of RET gene with anidentifiable clinical pathological features, is found to be involved in the pathogenesisof NSCLC as well as the invasiveness of tumors，and its treatment is effective by RETinhibitor, suggesting that RET fusion gene may be a new target for individualizedtreatment to the subgroup of NSCLC. This article reviews the structuralcharacteristics of RET fusion gene and expression model in clinical samples, andtreatment of NSCLC.