Study Of Pharmacy Part Of Gui-Gan Dripping Pills

Gui-gan pills prescriptions from shang-han-lun,it can helps heart-yang.and it only composed of Ramulus Cinnamomi and Glycyrrhizae.but it Provides the basis of to treat heart-yang insufficient. In this study, is the guidance of the theory of Chinese medicine,use of modern science and technology developed antiarrhythmic new Chinese medicine Gui-gan pills.And study the extraction process.the volatile oil inclusion process,molding process,quality standards and other aspects of the study.The main contents are as follows:l.The study of extraction processAs the evaluation index to the extraction rate evaluation of Cinnamon volatile oil.using the composite design-response surface methodology to optimizing the process of the extraction process, the best parameters are as follows:9times the amount of water immersion1h, the steam distillation time is8h. As the evaluation index to the total value of OD of dry extract yield, total flavonoids and total saponins. using the composite design-response surface methodology to optimizing the process of the the extraction Proces of Glycyrrhizae.the the best parameters are as follows:10times the amount of ammonia concentration of0.2%of the75%ethanol. refluxed time isl.7h.2.the study of guizhi volatile oil inclusion processusing HPLC method to test the content of cinnamic aldehyde in theβ-CD inclusion complex. As the evaluation index to the rate of β-CD inclusion complex.thecontent of cinnamic aldehyd.and the yield of P-CD inclusion complex.Using the composite design-response surface methodology to optimizing the process of Guizhi volatile oil inclusion, the best parameters are as follows:the ratio of β-CD and volatile oil is7:1. the inclusion temperature is35℃and the inclusion time is38min.3.The study of extract purification processAs the evaluation index to the dry extract yield, total flavonoids and total saponins.using the D101macroporous resin licorice extract purification process. the best parameters of extracting purification process are as follows:0.6times the concentration of the sample solution, the flow rate is2.5BV/h,the adsorption time is6h, the elution of ethanol is70%and the eluent is6BV.4. the study of preparations molding processAs the evaluation index to the appearance quality/the pill weight coefficient of variation and the disintegration of the pills.Using the composite design-response surface methodology to optimizing the pills molding process, the best parameters of molding process are as follows:the ratio of drug and matrix is1:2.5, the feed temperature is79℃, the temperature of the cooling column is5～10℃the dropping distance is6cm and the drip rate is33drops/min.3.3licorice.5. the study of quality standardsusingUsing TLC method to qualitative identification of Guizhi; using HPLC method to determination the content of cinnamic aldehyde, glycyrrhizin, glycyrrhizin.The results showed that the spots are clear,the separation,the repeatability and the Specificity of the method are well.The linear relationship of the HPLC method are precision, stability, repeatability and recoveries are eligible.6. Preliminary preparations stabilitythe results show that the preparations stability of3batches are good in three months.