The Microencapsulation Reduce Chinese Medicine Extract Powder Hygroscopic And Evaluation

Hygroscopic affect an important factor of the traditional Chinese medicine extract powder and its quality of prescription preparations.especially containing polysaccharides and saponins extract powder, moisture absorption is particularly prominent. Therefore, hygroscopic Chinese medicine extract powder for the study. microencapsulated to reduce the moisture absorption of the extract powder. to improve the moisture resistance of the drug, thereby improving the quality of Chinese medicine and its preparation.Poria mainly composed of polysaccharides and triterpenes. modern research Poria can enhance the immune function Pachymaran significant anti-tumor and Paul liver injury. Laboratory preliminary study found that the The extract powder Poria mention there is a strong moisture absorption, for several hours in the air that is bonded into a group. In this paper.the drug as a model drug, microencapsulated to maximize the reduction of moisture absorption of the extract powder and its preparation. The main contents are as follows:The the content Pachymaran evaluation indicators the orthogonal test the microwave reflux extraction process optimization, to determine the best process:temperature80C-extraction40min. the amount of solvent1:30, microwave power600W.Single coacervation the Poria extract powder microencapsulated phase.will extract obtained extract powder. drug loading and encapsulation yield index.the best preparation conditions for the use of central composite design-response surface method is preferably microcapsules. Results:The capsule heart capsule material ratio of1:3.57. temperature48.5℃. speed702r/min. The microcapsules preparation process-particle size distribution and stability to meet the requirements.Compare Poria extract powder and Pachymaran of microcapsules relative critical humidity, particle size distribution, bulk density, angle of repose. specific surface area. zeta potential found:Pachymaran microcapsules moisture absorption is reduced, relative to the critical humidity increase. Particle size increases, the increased bulk density, angle of repose to reduce the increased mobility of the specific surface area decreases zeta potentials increases.Absorption mechanism to explore:the Poria extract powder hygroscopic particle size is not regular, large surface area. and thus specific surface free energy zeta potential. Specific surface free energy of the large zeta potentials low causes the instability of the extract powder.easy to combine with the water molecules in the air. reducing the specific surface free energy and reaches a steady state.