Research Of3D Arterial Spin Labeling In Acute Traumatic Brain Injury

ObjectiveTo explore the diagnostic value of3-dimensional arterial spin labeling (3D ASL) technology in patients with acute mild traumatic brain injury (TBI).To study whether3D ASL can effectively reflect the cerebral hemodynamic changes in patients with acute mild TBI, provide objective imaging evidence for clinical diagnosis and treatment.Materials and Methods43cases of acute mild TBI patients and20healthy volunteers participated in routine MRI,3D ASL,3D-T1BROVA, DWI and SWAN scan. Using the software of GE functool4.5for data post-processing of3D ASL, SWAN and DWI scan.To measure cerebral blood flow (CBF) values of bilateral anterior, median and posterior cerebral artery areas in volunteers and patients with acute mild TBI.To measure the CBF value of local cerebral parenchymal hypoperfusion area and contralateral mirror area of the acute mild TBI patients. Contrastive analysis was made on volunteers’cerebral blood flow (CBF) values of bilateral anterior, median and posterior cerebral artery areas; contrastive analysis was made between the CBF value of brain parenchyma of the acute mild TBI patients who was found no obvious hypoperfusion area and the volunteer’s CBF value; contrastive analysis was made between the CBF value of local cerebral parenchymal hypoperfusion area of the acute mild TBI patients and that of contralateral mirror area.ResultsThere were six epidural hematoma,15subdural hematoma,9cases of subdural effusion,15cases of SAH,33cortical contusion,14local hematoma,12cerebral white matter shearing injury and77local hypoperfusion area in43patients with mild acute TBI. The right side of regional cerebral blood flow values of the Volunteers’ anterior,middle and posterior cerebral artery area were53.49±6.04,56.22±4.77,59.01±6.90(ml·100g-1·min-1).The left side of rCBF values of the volunteers’ anterior,middle and posterior cerebral artery area were52.94±5.27,55.62±3.71,60.44±5.97(ml·100g-1·min-1).The right various parts of cerebral arterial blood supply area compared with the left, P values were0.442,0.505,0.106, and the difference was not statistically significant (P>0.05). The brain parenchyma rCBF value of the acute mild TBI patients’ right side of the centrum semiovale which is not partial hypoperfusion was46.15±11.92(ml·100g-1·min-1),The rCBF value of volunteers’ various parts of cerebral arterial blood supply area in right centrum semiovale was56.24±6.29(ml·100g-1·min-1), and the difference was statistically significant (P<0.01). The rCBF values of the acute mild TBI patients’ local hypoperfusion area of the brain and the contralateral mirror area were42.82±10.41,51.56±12.14(ml·100g-1·min-1), and the difference was statistically significant (P<0.01).Conclusion1.3D ASL perfusion technique can effectively get cerebral hemodynamics information in patients with mild TBI to make an objective assessment of their CBF values,and it is of great significance for clinical diagnosis and treatment of patients with mild TBI.2.There were varying degrees of whole-brain CBF reduce in acute mild TBI patients.There were CBF values reduce in cerebral contusion sites.Non contusion site is also likely to exhibit local hypoperfusion.3.3D ASL is a fully non-invasive examination.It is simple, repeatability, and can be widely used in clinical.