| Objective: to assess brain venous phase value change with age, gender, andlocation using SWI, and to exploit the correlation between iron positions in nuclei andvenous oxygen concentration in healthy volunteers and multiple sclerosis (MS) patients.Materials and methods: Forty-four patients(12males,32females; mean age36.89±10.52years) with MS and56age-and gender-matched healthy volunteers(13males,43females; mean age37.13±12.25year) performed conventional MRI (axialT1WI, T2WI, fluid attenuated inversion recovery (FLAIR) and SWI examinations. Thephase values were measured respectively in bilateral basal vein (BV), deep middlecerebral vein (DMCV), internal cerebral vein (ICV), superior thalamostriate vein (STV),frontal bone intravenous (FMV), parietal medullary veins (PMV) and occipitalmedullary veins (OMV), and then in bilateral head of caudate nucleus (HCN), globuspallidus (GP), putamen(PUT), thalamus (THA), pulvinar thalamus (PT), substantianigra (SN), red nucleus (RN) in all subjects. The comparison of phase value was takenbetween the different veins, between in controls and in MS patients. The correlations ofphase values between cerebral veins and the deep gray nucleus were done by Spearmancorrelation analysis.Result:1.In healthy volunteers, the phase value of DMCV was lowest (542.05±118.97;P<0.05), and that of ICV was highest (884.03±146.51; P<0.05). Phase values of BVand STV were771.12±138.93and783.26±137.93. No significant correlation wasfound between phase values in all veins and age (P>0.05), and no venous phasedifferences were present in gender and side (P>0.05). Phase value of FMV, PMV andOMV is lower than those of cerebral deep vein(P<0.05). Phase value of PMV (74.22±17.74) is larger than that of FMV and OMV. 2. In healthy people, the positive phase correlations were found between vein (BV,DMCV, STV) and the some deep gray nuclei (HCN, PUT, GP), while the negativephase relations were present between bilateral HCN, PUT, GP, and white mattermedullary venous (P<0.05).3. Venous phase comparison between MS patients and controls In all of44MSpatients, the mean phase values of BV, DMCV, ICV and STV (597.40±39.80,331.45±27.85,674.95±29.75,558.15±34.75) were significantly lower than those in the controls(781.35±21.65,542.05±19.65,900.05±20.75,783.25±21.65, P<0.05). Phase value ofFMV is higher in MS than in controls (67.15±5.50, P<0.05). No obvious differences ofphase values in PMV and OMV were found between MS and the healthy volunteers(P>0.05).4. Correlation of phase value between veins and deep nuclei in MS The phasevalue of BV was negatively correlated with bilateral PUT (rR=-0.473, P=0.015; rL=-0.452, P=0.020); while the phase value between other vein and the nucleus had nocorrelation (P>0.05).Conclusion1.The phase value in brain vein, which reflect of the blood oxygen content, has noage-dependence, no gender and side differences in healthy people. Phase value ofcerebral veins is related with those of the deep brain nuclei.2. The decreased phase values of cerebral veins in MS patients is regarded ashypoxia in brain tissue relative. However, gray nucleus iron deposition is notdetermined by decreased blood oxygen content in MS. |
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