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The Left Atrial Structure And Function Changes In Patients With Paroxysmal Atrial Fibrillation And The Morphological Characteristics Of Local Potential For Effective Lesions During Circumferential Pulmonary Vein Isolation In Patients With Paroxysmal Atria

Posted on:2014-10-28Degree:MasterType:Thesis
Country:ChinaCandidate:T QiuFull Text:PDF
GTID:2254330425458315Subject:Internal medicine
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Part1The structure and functional changes in patientswith paroxysmal atrial fibrillationObjectives: To investigate the left atrial structure and function changes inpatients with paroxysmal atrial fibrillationMethods:57patients with paroxysmal atrial fibrillation in our hospital wereselected as the experimental group, while choose43patients with sinus rhythm asthe control group. The general information of all the patients were collected,such asage, gender, body mass index and medical history. The color flow Doppler and tissueDoppler imaging (TDI) were used to observe the structure and function of the leftatrial in two groups, including the left ventricular ejection fraction (LVEF), left atrialdiameter (LAD), left atrial area(LAA), left atrial volume (LAV), determination of themitral late diastolic blood flow peak velocity (VA), measured mitral valve area(Smv) at end-diastolic time,left atrial ejection force (LAF), early diastolicmyocardial tissue movement peak velocity (E’) and late diastolic myocardial tissuemovement peak velocity (A’) in tissue Doppler.Result: There were no significant differences in general information betweenthe control group and the experimental group (P>0.05). It was found that the LAD,LAA and LAV of the experimental group were significantly increased (P<0.05),and the LAF, E’, A’ and VA of the experimental group were significantly decreased(P<0.05).Conclusion: Left atrial structure and function in patients with paroxysmal atrialfibrillation have changed, the left atrial diameter of the patients with paroxysmalatrial fibrillation is longer than that in people with sinus rhythm and their left atrialfunction is lower than that in people with sinus rhythm. Part2The morphological characteristics of local potential oneffective lesions during circumferential pulmonary veinisolation in patients with paroxysmal atrial fibrillationObjective: To explore the morphological characteristics and clinicalsignificance of local potential on effective lesions during circumferential pulmonaryvein isolation in patients with paroxysmal atrial fibrillation.Methods: The circumferential pulmonary vein isolation (CPVI) in57patientswith paroxysmal atrial fibrillation (PAF) was finished guided by Ensite NavX andthe potentials were recorded. Pulmonary vein antrum was divided into eight regions,and the regularity of the effective lesions was analysed. The invalid ablation lesionswere selected randomly to observe the morphological characteristics of localpotential.Results:1.57patients with paroxysmal atrial fibrillation patients have done thecircumferential pulmonary vein antrum ablation successfully, with operative time193±48.7min, X-ray exposure time38.37±18.4min.2. PVA’s potential generally presented as DP or CFAEs. Most of the effectiveablation point was located on the left front, the middle of the left anterior, the top ofleft side. On the right PVA is most common in the middle of the right after, rightafter the upper and right front.3. Compared those with the invalid ablation points, the duration, amplitudeand prevalence of CFAEs were more frequent at the effective ablation points. TheP-wave delay time of the effective ablation lesions was shorter.Conclusion:1. Both CFAEs and DP potentials can be recorded in various parts of the PVA ofpatients with paroxysmal atrial fibrillation. Most of the effective ablation point is located on the left front, the middle of the left anterior, the top of left side. On theright PVA, it is most common in the middle of the right after, right after the upperand right front.2. During the circumferential pulmonary vein isolation (CPVI), the duration,amplitude, prevalence of CFAEs were more frequent and the P-wave delay time wasshorter at the effective ablation lesions. Combined with the morphologicalcharacteristics of local potential on effective lesions may help the procedure of CPVI,increase the success rate and reduce the incidence of complications.
Keywords/Search Tags:Paroxysmal atrial fibrillation, Doppler, Structure of the left atrial, Function of the left atrialParoxysmal atrial fibrillation, Local potential, Circumferentialpulmonary vein isolation(CPVI), Radiofrequency ablation
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