Synthesis Of Tigecycline

Objective: To improve the synthesis of tigecycline.Methods: The tigecycline was preparated by a three-step procedurefrom minocycline. Firstly, minocycline was converted to the intermediate9-nitro-minocycline by nitration. Then9-nitro-minocycline was reduced to9-amino-minocycline, followed by condensation with the N-t-Butylglycineacid chloride hydrochloride.Results: Chemical stucture of tigecycline was confirmed byLC-MS,1H-NMR and etc.Conclusion: A more reasonable operational path for the manufacturingprocess of tigecycline has been developed.