Changes In Serum So Of Post-menopausal Women With Osteoporosis Treated RhPTH(1-34)

Objective：To compare the difference of serum sclerostin amongpostmenopausal women and the change of serum SO treated rhPTH（1-34）,and investigate the relationship of serum SO and E₂,bone mineraldensity,further to explorer the relationship of serum SO and Osteoporosis.Methods：95postmenopausal women were divided into normalBMD group（n=41,T＞-1SD）and osteoporosis group（n=54,T≤-2.5SD,or fracture of one or more and T＜-1SD）on the basis of whose bonemineral density.All participants were measured height,weight,body massindex（BMI）,alkaline phosphatase（ALP）,serum E₂,serum calcium,serum phosphate and sclerostin（SO）by ELASA after collected fastingvenous blood and centrifuged.The patients in osteoporosis group weretreated with recombinant human parat-hyroid hormone （1-34）,all thetreatments lasts twelve months.Serum sclerostin and other biochemicalindicators were measured in osteoporosis group after6months and12months treatment. Results：（1）The osteoporosis group in BMD,ALP,E₂and So isdifferent with the normal BMD group：The level of the bone mineraldensity of lumbar vertebrae2-4,the bone mineral density of left femoralneck and E₂were decreased by17.71%,26.37%and31.79%withcompared normal BMD group, Serum SO and ALP levels of theosteoporosis group were higher than those in the normal BMD group, andthe differences were significant（P<0.05～P<0.01）,but there were nosignificant difference between the two groups of height,weight,BMI,serum calcium and phosphorus.（2）The serum E₂and BMD of lumbarvertebrae L2-4and left femoral neck were negative correlation with SO[thecorrelation coefficients were r=-0.518（P<0.001）,r=-0.225（P=0.045）andr=-0.221（P=0.49）]ï¼› Age and postmenopausal time were positivecorrelation with SO[the correlation coefficients were r=0.470（P<0.001）andr=0.406（P=0.001）].（3）The BMD of lumbar vertebrae2-4and left femoralneck and serum ALP were increased gradually with treated rhPTH after6months and12months with the rhPTH（1-34） treatment,and thedifference was especially（P<0.05～P<0.01）.With the prolongation of thetreatment time increased,the serum SO was reduced gradually and thedifference was statistically significant（P<0.05～0.01）；serum calcium,phosphorus with the prolongation of treatment time increased,but therewas no significant difference before and after the treatment,and E₂had noobvious change. Conclusion：Serum SO was increased in postmenopausal women,it was related to E₂and BMD,and was reduced gradually with treatedrhPTH. SO may participate in the development of postmenopausalosteoporosis.