Analysis Of Neonatal Respiratory Distress Syndrome

Objective: To investigate the gestational age distribution of neonatalrespiratory distress syndrome, the different clinical characteristics ofdifferent gestational ages and influencing factors of prognosis, so as toprovide advice for the treatment and improving prognosis of NRDS.Methods：Data of148NRDS were collected retrospectively inJanuary1st2012～June302012in the Children’s Hospital of ChongqingMedical University. Among them,78cases whose gestational age less than34weeks， defined as early preterm infants group，34cases whosegestational age from34weeks to less than37weeks，defined as latepreterm infants group，and36cases whose gestational age over37weeksdefined as full-term infants group.(1) Analysis the gestational agedistribution of NRDS.(2) All these NRDS infants were grouped to3groupsaccording to gestational age were analyzed by the following aspects：general situation， perinatal factors， chest X-ray classification，complications and sputum culture，treatment，discharge imformation andprognosis.(3) All the148cases were divided into two groups according toprognosis：improved or cured group with85cases，abandoned or deadgroup with63cases. Compare clinical data of two groups and explore thefactors affecting prognosis of NRDS. All statistical data were analyzed bySPSS17．0software. Results：The gestational age distribution with early preterm infants,late preterm infants, full-term infants were52.7%、23.0%、24.3%. Theproportion of male in different gestational age group was high. There Weresignificant differences of different gestational age groups in followingfactors：birth weight，twins or polyembryony，Apgar score1min, cesareandelivery, antenatal preventive use of glucocorticoids, PROM, intracranialhemorrhage, time of ventilation and oxygen therapy，clinical pathway，prognosis， hospitalization time and expense. For different prognosisgroups，the following factors were significant different：birth weight，Apgarscore1min、5min，gestational age，Chest X-ray classification，number ofPS application，pulmonary hemorrhage，PAH. By multivariate logisticregression analysis, the number of PS application, Chest X-rayclassification，Apgar score1min were found to be independent influencingfactors of prognosis.Conclusion: NRDS mainly occurred in preterm infants，late pretermand full-term infants still accounted for a considerable proportion. Thedifferences of three gestational age groups in general situation，perinatalfactors， complications，treatment， discharge imformation and prognosiswere statistically significant. Diagnosis and treatment for NRDS should bebased on differente gestational age. Avoiding asphyxia，the early use ofexogenous PS and receiving chest X-ray，were significant meaningful forimproving prognosis of NRDS.