The Inoculation Of Hepatitis B Vaccines And Sero Epidemiological Survey Of Hepatitis B In Xinzhou And Donghugaoxin District Of Wuhan

Objective: This study aims to explore the effect of immunization with hepatitis Bvaccine after implementation of the2006survey, so as to provide pertinent testimony tobetter control and treatment hepatitis B virus and provide scientific basis for government tomake measures to prevent Hepatitis B further. Furthermore, to evaluate the prevalence rates,distribution characters and genotype of HBVseromarkers in Wuhan city of Xinzhou andDonghugaoxin region of different age people and different gender, as well as to explore thepossible risk factors of HBV infection.Methods: Multistage systematic sampling was used to selected informant amongXinzhou and Donghugaoxin region. The informant was surveyed using a standardquestionnaire including the history of hepatitis B, history of hepatitis B exposure, history ofhepatitis B immunization and so on. The blood samples were collected and detectedsero-marker by Enzyme-linked immunosorbent assay (ELISA). Input all the data into theEpidata3.0database, and use SPSS13.0to make statistical analyzing.Results:(1) Demology Features: The percent of informant among Xinzhou region was71.21%and Donghugaoxin was28.79%; the constitution of informant age groups of1-9,9-19and20-80was16.09%、29.53%and54.38%; the ratio between male and female is1:0.99; the Han nationality took99.5%among population; the constitution of unmarried, married, dissociation and others was42.89%、45.76%、1.27%and10.15%; the top three joboccupation were students (28.93%), farmer (23.38%) and worker (22.17%); the junioreducational background constituted58.34%of population and the senior backgroundconstituted27.34%.(2) Inoculation of hepatitis B vaccines: The hepatitis B vaccine inoculation rate ofXinzhou region was63.60%among the population. The hepatitis B vaccine inoculation rateof Donghugaoxin region (42.75%) was significantly lower than Xinzhou region. Theinoculation rate and complete inoculation rate was significantly decreased by age increased.It was significantly higher in male than female only in Xinzhou region.(3) Epidemic serology features of the sign of HBV infection: HBsAg, HBsAb and HBVprevalence rates of people in Xinzhou and Donghugaoxin was3.49%and5.16%;70.97%and68.30%;17.81%and20.39%. The HBV prevalence rate was significantly higher amongfemale than male in Xinzhou region, however, the other sigh as HBsAg and HBsAbprevalence show a higher prevalence in male than female in both regions, and no significantdifferences were found in those above results.(4) Composite models of HBV seromarkers: Nine models of HBV seromarkers weredetected in the survey. The model solely positive for HBsAb accounted for60.07%; and themodel negative for all of the five HBV seromakers account for24.88%. The third highestcomposite models of HBV seromakers were positive both for HBsAg and HBsAb.(5) The analysis of risk factors for HBV infection: Thought logistic regression analysis,the main risk factor of HBV infection were age and donate blood with paid, the OR value ofthese factors were0.68(0.63-0.74) and3.13(1.32-7.43), respectively.Conclusion: Xinzhou and Donghugaoxin region implemented the program of hepatitisB vaccines in the children s immunization very well. However, women of child-bearing agein outlying district should be strengthen at boring in hospital in order to decrease the risk ofhepatitis B infection. In comparison with the1992and1996survey, the HBsAg prevalencerate were dropped largely. Though both Xinzhou and Donghugaoxin were middle epidemic area, two regions had achieved the goal set by2006to2010national hepatitis B controlprogram: the incidence of HBsAg positive rate should be controlled under7%until2010.We should still increased inoculation among population, and strengthen the implementationin the people of immunization program.