Research On Expression And Correlativity Of HDAC1, DNMT1, RECK In Cervical Cancer

Objective： To explore the expression and relationship of HDAC1(histonedecetylase1)、 DNMT1(DNA methyltransferase1)、 RECK (reversion-inducing-cysteine rich protein with kazal metifs）in cervical cancer.Methods： The expressions were detected of HDAC1、DNMT1、RECK by SPimmunohistochemistry method in40cervical cancers,35cervical intraepithelialneoplasia(CIN) and15normal cervical tissues to discuss clinicalpathologicalmechanism and correlation of them in cervical cancer.Results：The positive expression rate of HDAC1、DNMT1in cervical cancerand CIN were higher than in normal cervical tissue (P<0.05), while RECK was lower(P<0.05). The increased expression of HDAC1and DNMT1were correlated withdifferentiation grade of carcinoma (P<0.05), not with clinical stage and metastasis tolymph node (P>0.05). The increased expression of RECK was correlated withmetastasis to lymph node (P<0.05), not with differentiation grade of carcinoma andclinical stage (P>0.05). The expression rate of HDAC1and DNMT1in cervical cancerwas positively correlated (P<0.05), while both of the two indicators were negativelycorrelated with RECK (P<0.05).Conclusion：The high expression rates of HDAC1and DNMT1，while the lowof RECK may be related to the development of cervical cancer.