| Objective: To explore the expression of Galectin-3and MMP-2and their clinicalsignificances.Methods: Immunohistochemistry was used to detect the expression of Galectin-3andMMP-2in papillary thyroid cancer, thyroid adenoma tissues, nodular goiter tissues andthyroid adenoma tissues. Moreover，the relation of their expression to clinical pathologicalindex was analysizedResults: The positive expression rate of Galectin-3and MMP-2protein was bothsignificantly higher in papillary thyroid cancer than in normal thyroid tissues, nodulargoiter tissues and thyroid adenoma tissues(P＜0.05). The expression of Galectin-3inthyroid cancer tissues was not related to sex, age, diameter of tumor and lymph nodemetastasis(P＞0.05). The expression of MMP-2in thyroid cancer tissues was not related tosex, age and diameter of tumor (P＞0.05), but it was associated with lymph nodemetastasis(P＜0.05). The expression of Galectin-3and MMP-2protein was positivelycorrelated in papillary thyroid cancer tissues(P＜0.05).Conclusion:1. The highly expression of Galectin-3and MMP-2can act as an importantauxiliary method for the diagnosis of papillary thyroid cancer.2. The expression ofGalectin-3was not related to sex, age, diameter of tumor and lymph node metastasis. Theexpression of MMP-2in thyroid cancer tissues was not related to sex, age and diameter oftumor, but it was associated with lymph node metastasis, therefore, MMP-2may worth something to estimate whether PTCs with lymph node metastasis occurred in thepre-operation.3. The expression of Galectin-3and MMP-2protein was positivelycorrelated in papillary thyroid cancer. Joint detection of Galectin-3and MMP-2can behelpful for the diagnosis, treatment or prognosis of papillary thyroid cancer. |
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