Prevalence Of HPV Infection And Cervical Cancer Among Females In Ningbo

Objective: To understand the epidemiological characteristics of cervical cancer incidence andmortality and the prevalence of HPV infection among females in Ningbo. We aimed to provide thebasis for the optimization of the cervical cancer prevention strategies and the baseline prevalencedata of HPV prior to immunization programs of HPV vaccine.Methods: Using cluster random sampling method to extract Ningbo married women assubjects and their exfoliated cells of cervix were collected for HPV detection. Data on cervicalcancer in Ningbo from2006to2011were collected to calculate corrected incidence and thedifference among different age groups and areas.Joinpoint regression was used to study incidencetrend of cervical cancer. The method which Marc Arbyn described was used to correct themortality rates of cervical cancer. The crude death rate (CR) was calculated. The log-linearregression was used to analyze the time trends of cervical mortality rate and the weighted χ~2wasused to analyze the difference of the cervical cancer mortality rates between urban and ruralwomen.The software of EXCEL2003and SPSS17.0were used to carry out statistical analysis.Results:1.Totally1373cervical samples from Ningbo city were detected and185cases of HPV-positive were detected.The overall HPV precalence was13.57%and the standardized rate was9.66%(95%CI:1.56～17.77). The number of High-risk HPV cases were184and the prevalence ofHigh-risk was12.96%.2. HPV52was the most precalent type(2.26%), followed by HPV58(1.89%), HPV16(1.53%),HPV33(1.31%), HPV68(0.87%).3.The incidences of cervical cancer in40-59years old women range from20.96/lakh to38.87/lakh and higher than other age-groups’ women. The incidence of cervical cancer in Fenghuacity was17.18/lakh and higher than other two disease surveillance areas. No significance level wasfound in the incidence trend of cervical cancer.4.The uncorrected CR, CASR and WSR of cervical cancer during2002-2011were2.78/lakh,2.18/lakh and2.26/lakh，respectively. The corrected CR, CASR and WSR were5.19/lakh,4.07/lakh,4.21/lakh, respectively. The mortality rates of cervical cancer were increased with age（uncorrected χ~2trends=818.261，p=0.000；corrected χ~2trends=1563.041，p=0.000）. 5. The corrected CR fluctuated between4.41/lakh-5.99/lakh during2002-2011with nosignificant difference（EAPC：0.60%，95%CI：-0.30%，1.51%）, the CASR fluctuatedbetween3.52/lakh-4.60/lakh with decreasing trend（EAPC：-2.08%，95%CI：-3.63%，-0.40%）, the WSR fluctuated between3.51/lakh-4.85/lakh with decreasing trend（EAPC：-1.09%，95%CI：-1.88%，-0.20%）.6.Women in rural area maintained significantly higher mortality rate of cervical cancer thantheir urban counterparts（weighted χ~2=34.892，p=0.000）。Conclusions:1. The crude HPV precalence was13.47%and the standardized rate was9.66%. HPV52wathe most precalent type, followed by HPV58, HPV16, HPV33,HPV68.2.40～59years old women were in high risk of cervical cancer and women who live in rurarea were also in high risk of cervical cancer.The mortality rate of cervical cancer showed asignificantly decreasing trend during2002-2011in Ningbo, but maintaining a high level. Womein rural area maintained significantly higher mortality rate of cervical cancer than their urbancounterparts.