Changes Of Serum GLP-1after Glucose Tolerance In Gestational Diabetes Mellitus

Objective With the development of economy and the change of modern way of life, theincidence of GDM is rising year by year. In addition, the chance of development for T2DM afterdelivery has increased significantly, so the GDM has aroused more and more attention. Recently,the continuous deepening of the research in diabetes pathogenesis and drug therapy provides a newthinking for diabetes treatment. Through the determination of serum glucagon like peptide-1tounderstand the content of in cretin, comparing the GDM and newly diagnosed T2DM in cretin thedifferences about level and effect of gestational diabetes, we could explore the function and clinicalsignificance of GLP-1in GDM.Methods Patients were divided into two groups including36cases of24~36week GDM,40cases of T2DM. Fasting plasma glucose-stimulated after0.5,1,2and3h blood samples, theindicators of glucose, insulin and GLP-1, respectively calculate the rising rate and operatecorrelated analysis. The collected data will assess the changes and disparities in patients with a newdiagnosis of gestational diabetes and GLP-1blood glucose and insulin type2diabetes. The insulinsensitivity and β-cell secretion function were assessed by HOMA-IR and HOMA-β.Results Insulin and GLP-130in GDM group was higher than in T2DM group, but glucose wassignificantly lower. ΔG30/G0in GDM group was higher than that of in T2DM group(P<0.01), ΔGLP-130/GLP-10in GDM group was higher than that of in T2DM group(P<0.05), ΔGLP-160/GLP-10, ΔGLP-1120/GLP-10and ΔGLP-1180/GLP-10wereno significant statistical difference in two groups (P>0.05). ΔI30/ΔG30and ΔI60/ΔG60in GDMgroup was higher than that of in T2DM group (P<0.05). But ΔI120/ΔG120and ΔI180/ΔG180wereno significant statistical difference in two groups (P>0.05). Compared to T2DM group, HOMA-IR showed a significant increase (P<0.05). In contrast, the level of age and HbA1c suggested asignificant decrease (P<0.05) in GDM group.Conclusions GLP-1levels decreasing exists both in GDM diabetes and T2DM diabetes.GLP-1perhaps plays a great part in the pathogenesis and regulates glucose of GDM.