A Research Of Nesting Behavior In APPswe/Ps1dE9Double Transgenic Mice Of Alzheimer’s Disease

ObjectiveThe present study was aimed at observing the nesting behavior in APPswe/PS1dE9double transgenic mice of Alzheimer’s disease.MethodsThe APPswe/PS1dE9double transgenic mice and their non-transgenic littermates (that is the wild-type mice) at the age of3、6、12months old were observed by nesting construction with paper towels, then, their latency time when they initiate nesting construction and their nesting scores at the time point of2h,24h,48h were recorded.ResultsThe APPswe/PS1dE9double transgenic mice show longer latency time(P<0.05) and lower nesting scores at the point of2hours (P<0.05) from3months of age to12months.By the age of12months old, APPswe/PS1dE9double transgenic mice’s nesting scores decreased at all3time point compared to wild-type mice(2h:P<0.01;24h:P<0.0148h:P<0.001).Age was a significant effect on nesting scores in double transgenic mice (P<0.01) but not in wild-type ones(P>0.05).ConclusionThe APPswe/PS1dE9double transgenic mice were slower to initiate nesting construction and made worse nest during a short period of time compared to their non-transgenic littermates at age of3months old. The results show a genetic and age-dependent impairment of nesting behavior in APPswe/PS1dE9double transgenic mice.