Relationship Between Postoperative Hyponatremia And Glucocorticoid Usage In Patients With Pituitary Adenoma And Craniopharyngioma

This paper is geared towards studying the relationship between hyponatremia and glucocorticoid decrement after the patients’ Pituitary adenoma and craniopharyngioma operation.Methods:One hundred and thirty-four cases of patients with pituitary adenoma and craniopharyngioma who underwent surgical treatments in Wuhan Union Hospital from2008to2011were selected for this research. With the case-control method applied and the random number table utilized,42cases were randomly selected from the92patients with hyponatremia to form the case group. And the remaining42cases of patients without hyponatremia constitute the control group. Firstly, the single-factor logistic regression analysis was conducted for items such as gender, age, tumor types and postoperative usage of glucocorticoid. It was shown that at the inspection level of0.05, the influence of age on hyponatremia after surgeries of pituitary adenoma and craniopharyngioma was statistically different between the two groups (P=0.004); but there were no statistical difference in gender, tumor types and postoperative usage of glucocorticoid. Then the gender, age, tumor types and glucocorticoid reduction were included into the model together for multi-factor logistic regression analysis. The selected variable standard was0.05, and the excluded variable standard was0.15. The backward maximum likelihood autoregressive parameter estimation method was applied, whose results show that only the age was selected into the variables of the regression equation (P=0.004), with OR value of5.846, indicating that the age was a risk factor for the incidence of hyponatremia, which was occurred in patients over50years old5.846times as much as the patients below50. And the influences of glucocorticoid reduction, gender and tumor types on postoperative hyponatremia were all not statistically different.Results:The age contributes significantly to the logistic regression model (P=0.004), while the gender, age, tumor types and glucocorticoid decrement have less influence, indicating that age is the risk factor for postoperative hyponatremia.Conclusion:Age is one of the risk factors for hyponatremia after the Pituitary adenoma and craniopharyngioma operation. Hyponatremia cannot be explained independently by glucocorticoid decrement or hypocortisolism since it is a confluence of many integrated factors.