Basic Research On The Construction Of Real-time Monitoring Models In Microwave Thermotherapy

Microwave ablation(MWA) has been used in clinical treatment as an important hyperthermiamethod, and its main principle is heating proteins of tumor cells by oscillation of charged ions andwater molecules in the tissue caused by microwave radiation reach their solidification temperature todeath, and the treatment has a significant curative effect. But during clinical application it cannotachieve real-time efficacy evaluation and control of dosage. This paper raises a concrete proposal tosettle the problems above. Minimally invasive functional near infrared spectroscopy (fNIRs) andmicrowave treatment technique are organic combined to evaluate the efficacy by real-time acquiretissue parameters in the process of microwave therapy, and it provide theoretical evidence for accuratemonitoring of clinical surgery.The main contents:1. Simulating the temperature distribution of tissue with MWA by using finiteelement analysis software according to the application of finite element method for bio-heat transfer.Secondly, the author deduced the volume model based on the simulation. The temperature distributionmodel decided instantaneous temperature at any position of the tissue while the volume modeldecided the size of effective lesions at any microwave power and time;2. Testing real-time tissueparameters by using fNIRs technology during microwave hyperthermia and thus determinating ofreduced scattering coefficients) as a real-time monitor factor;3. Based on a lot of experimentaldata analysis, we obtained a reliable parameter (’s) used to real time monitor operation, andestablished a relationship model between parameters of efficacy evaluation and microwavetherapeutic parameters (power: P and lasting time: t). And we can achieve an ideal evaluation oftherapeutic efficacy through mathematical models.The creativeness of this study is as follows:1.Proposed a real time efficacy evaluationtechnology based on MWA using fNIRs technique;2.Proposed a simulation method of thetemperature field during microwave ablation based on finite element and deduced the temperaturedistribution model and the volume model;3. Established a mathematical model of efficacy evaluationthrough experiments of vitro porcine liver which has great significance to reduce the surgeryblindness and improve the therapeutic effect.