Comparison Of Cognitive Function Between Patient With Hemodialysis And Peritoneal Dialysis

ObjectiveTo assess the cognitive function in long-term stable hemodialysis and peritoneal dialysis patients, and to compare the effects of different dialysis modality on cognitive impairment.MethodsA cross-sectional study was performed in the subjects among62patients with long-term stable hemodialysis patients and75cases of peritoneal dialysis patients, who were examined with neuropsychological tests using the Montreal Cognitive Assessment (MoCA).ResultsAfter adjusting for age, gender, years of education, the proportion of high blood pressure and diabetes, pre-dialysis hemoglobin, serum albumin, calcium, parathyroid hormone, the prevalence of HD group suffering from cognitive dysfunction (MoCA score<26) was75.8%, and the PD group was62.7%, the result was similar(P=0.099>0.05). And for the MoCA sub-items:visuospatial/executive, naming, attention, language, abstraction, memory, orientation depending on the space/ability to execute, naming, attention, abstraction ability, memory, orientation and total score, the HD group was similar to PD group(P=0.720, P=0.311, P=0.263, P=0.387, P=0.465, P=0.724, P=0.104, P=0.516).ConclusionLong-term stable hemodialysis and peritoneal dialysis patients were had a high prevalence and extensive cognitive impairment, which has a serious impact on the self-management skills and drug adherence, but no obvious advantages and disadvantages of the two dialysis modality on cognitive function.