Characteristics Analysis Of Related Risk Factors For Pancreatic Cancer

Objective Pancreatic cancer is a life-threatening tumor, which has an upward trend in its incidence yet a fairly low survival rate. Although surgical treatment is the treatment of choice for its relatively high chance for remission, only a small number of patients are suitable for radical excision. Therefore, early diagnosis and treatment of this disease would significantly improve the prognosis and survival rate of the patients. The purpose of this study is to analyze and evaluate the related risk factors for pancreatic cancer, screening for high-risk populations, as well as providing the basis for early prevention and treatment of pancreatic cancer.Methods The clinical data are taken from patients in the Second Affiliated hospital of Zhejiang university, School of medicine during April2007to August2012. For this case-control study, records of407pancreatic cancer patients were retrospectively analyzed. Physical examination records of1141healthy patients, whose age and sex matched the above were used as the control. Unconditional logistic regression model was adopted to analyze patients’body mass index (BMI), history of smoking, alcohol, hypertension, diabetes, hepatitis B and dyslipidemia, which are the suspicious risks associated with pancreatic cancer.Results Single factor analysis showed the following results:smoking is highly associated with the incidence of pancreatic cancer (OR=1.8,95%CI1.4-2.3), especially in heavy smoking, which has a greater risk (OR=3.6,95%CI2.7-4.9); While small consumption of alcohol have no obvious relation, heavy consumption of alcohol greatly increases the risk (OR=2.7,95%CI1.9～3.8); Hypertension increases the risk of pancreatic cancer (OR=2.5,95%CI2.0～3.3); The result of fasting blood-glucose were compared in two groups which showed that case group had significantly higher fasting blood-glucose than the control group (P<0.001), and diabetes mellitus is one of the related risk factors for pancreatic cancer (OR=6.3,95%CI4.5～9.0); The result of total cholesterol (OR=9.157,95%CI5.859～14.312), triglycerides (OR=6.175,95%CI4.376～8.713), LDL (OR=36.614,95%CI23.366～57.373) showed a correlation between dyslipidemia and pancreatic cancer although HDL has negative correlation with the incidence (OR=0.267,95%CI0.202～0.354); Additionally, BMI and HBV had no significant correlation with pancreatic cancer (P>0.05). Due to multi-factor Logistic regression analysis, heavy smoking (OR=3.044,95%CI1.972～4.700), heavy drinking (OR=2.111,95%CI1.293～3.448), hypertension (OR=2.129,95%CI1.476～3.070), diabetes (OR=4.516,95%CI2.784～7.326), triglycerides (OR=4.075,95%CI2.590～6.410) and LDL (OR=30.135,95%CI18.434～49.262) are the independent risk factors for pancreatic cancer, of which, each has different statistical significance (P<0.05).Conclusions Pancreatic cancer have significant correlations with smoking, alcohol, hypertension, diabetes mellitus and dyslipidemia, among these heavy smoking and heavy alcohol consumption, hypertension, diabetes, triglycerides and LDL are the independent risk factors for pancreatic cancer. Effective basic disease control and good living habits also have a great significance for the prevention of pancreatic cancer.