Analysis Regulatory T Cells In Peripheral Blood Of BPH Patients And Detect Its Significance

Objective：Seeking T cell subsets that CD4~+T cells、CD8~+T cells、 CD4~+CD25~+T cells、CD8~+CD28~-T cells、CD4~+CD25~-T cells and CD8~+CD28~-T cells expressdifference and significance in the peripheral blood in the patients with hyperplasia ofprostate.Methds：Selected30patients with prostate hyperplasia and normal control group20cases in people’s hospital of deyang, with flow cytometry instrument detectexperimental group’s T lymphocyte expression in the peripheral blood. UsingSPSS17.0for statistical that analysised the T lymphocytes’ expression differences inperipheral blood with prostate hyperplasia patients and the normal control group.Results：（1） Prostate hyperplasia patients’ CD4~+T cell expression numbersignificantly higher than the normal control group before and after the treatment;Prostate hyperplasia patients’ CD8~+T cell expression number obviously lowe than thenormal control group before and after the treatment;Prostate hyperplasia patients’CD4~+T/CD8~+T cell expression number obviously higher than the normal control groupbefore and after the treatment.（2）Prostate hyperplasia patients’ expression of CD4~+Tcell numbers significantly higher than the normal control group before and after thetreatment; Prostate hyperplasia group’s expression of CD8~+T cell numbersobviously lower than normal control group before and after treatment; Prostatehyperplasia patients’CD4~+/CD8~+T were observed obviously higher than normalgroup.（3）The number of CD8~+CD28~-T cells in Prostate hyperplasia patients issignificantly lower than normal control group before the treatment, after thetreatment,the number is significantly higher than normal control group; The numberof CD8+CD28+T cells in Prostate hyperplasia patients is significantly higher thannormal control group before the treatment, after the treatment, the number comparedwith the control group has no statistical significance.Conclusion：The changes of peripheral blood T lymphocytes in Prostate hyperplasiapatients is close related to the BPH’s occurrence and development.Inflammatoryimmune may plays an important role in prostate hyperplasia’s occurrence anddevelopment.