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Packet Selection In Clinical Trials Based On The Balanced Loss Function

Posted on:2014-11-26Degree:MasterType:Thesis
Country:ChinaCandidate:J LiFull Text:PDF
GTID:2254330401981941Subject:Probability theory and mathematical statistics
Abstract/Summary:PDF Full Text Request
The doctor-patient relationship requires clinical trials also have scientific and ethical. TheNeyman allocation of make the power reach the maximum value,andall the clinical trial participants assigned to higher success rates of group can meet the ethicists toensure that the best interests of the subjects of the requirements. But not at the same time betweenscience and ethics to find a balance point.This paper discusses two trials were carried out: one is the Connor et al study drug AZT, anantiviral reduced the risk of HIV mother to child transmission size. Another is2009Julyoccupation and health magazine "alprostadil combined with Mecobalamin on diabetic peripheralneuropathy curative effect observation of alprostadil combined with mecobalamin and" contrastalone Mecobalamin on diabetic peripheral neuropathy curative effect.As a result of the disease treatment of the consequences of failure are different, so the weightbalanced loss function of choice is also different, according to the selected so that the groupingscheme balancing selection for the actual need of loss function.
Keywords/Search Tags:Neyman allocation, power, the minimum failure rate, balance loss
PDF Full Text Request
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