Combination Of VEGF, CT And SCC-Ag Predicts Pelvic Lymph Node Metastases In Squmous Cell Cervical Carcinoma

Objective: To evaluate the diagnostic value in invasive cervical carcinoma lymphnode metastases by the expression of vascular endothelial growth factor (VEGF), CTexamination and SCC-Ag detection. Methods: Sixty-eight cases with cervical carcinomaconfirmed by surgery and pathology were examined with plain and enhanced CT scanningand serum SCC-Ag detection, the resected tumor specimens were immunohistochemicallystained for measuring VEGF expression. We analysed the diagnositic value of pelviclymph node metastases by three methods.(lymph node pathology results were as thestandard). Results: To pelvic lymph node metastases in invasive cervical carcinoma, thepositive expression of VEGF sensitivity was35.3%, specificity was94.1%, thecoincidence rate was64.7%. Sensitivity of CT examination was50.0%, and specificitywas82.4%, the diagnostic coincidence rate was66.2%. Sensitivity of CT combined withVEGF was64.7%, specificity was76.5%, the coincidence rate was70.6%. Sensitivity ofCT combined with SCC was79.4%, specificity was50.0%,the coincidence rate was64.7%. Conclusion: The specificity of the expression of VEGF Protein to diagnose pelviclymph node metastases was highest, it could diagnose the patients without lymph nodemetastases. When VEGF, CT, and SCC-Ag were examined at the same time, thesensitivity to diagnose pelvic lymph node metastases was highest, it could diagnose thepatients with lymph node metastases.