Effect Of Conservative Fluid Management Strategy On The Outcomes In Patients With Acute Lung Injury

Objective: To evaluate the effect of conservative fluid management on theoutcomes in patients with acute lung injury(ALI). Methods: Randomized controlledtrials (RCTs) were identified from CNKI、CBM、Wanfangdata、VIP、Pubmed、CENTRAL、Springer、Elsevier、Critical Care Medicine、Intensive Care Medicine、TheAmerican Journal of Respiratory、Critical Care Medicine and Chest. Results: Fourteenstudies involoving7in English，7in Chinese were identified. There were2603cases, ofwhich1108patients in conservative fluid management group,1495patients inconventional fluid management group. There were no statistical differences between twogroups on mortality(P=0.13). The results of meta-analysis indicated that there werestatistical difference between two groups on ventilator-free durations days (P<0.00001)、days in the intensive care unit(P<0.00001)、oxygenation index（P<0.00001）and serumlactate（P<0.00001）.Conclusion: No benifical effect of conservative fluid managementstrategy on the mortality is observed in the ALI patients. And the ventilator-free durationsbecome elongated and shortened days in the intensive care unit improve oxygenationindex and serum lactate. However, further trials of a larger sample size and a higherquality are warranted.