The Relationship Between Peroxisome Proliferators Activated Receptor Gamma C161-T Gene Polymorphism And Coronary Heart Disease

Objective:To compare peroxisome proliferators activated receptor gamma (PPARy) C161-T gene polymorphism between CHD group and the control group, discussing the association between PPARγC161T gene polymorphism and CHD and coronary artery stenosis.Methods:A case-case study was designed in this study. We selected422examples in Tianjin Chest Hospital and measured their height, weight, gender, blood pressure, CHO, TQ HDL-c, LDL-c, VLDL-c, FBG,2hBG, collected medical history. All examples were grouped into CHD group (322examples) and the control group(100examples), according to the results of coronary angiography(CAG). According the medical history, symptoms and laboratory reports, we grouped the CHD group into SAP group(84examples), UAP group(185examples) and AMI group(53examples). According to the number of stenosed coronary vessel, single vessel lesion group(145examples), double vessel lesions group(106examples) and triple vessel lesions group(71examples). We grouped Gensini score into into A group(75examples), B group(82examples), C group(71examples), D group(94example). According to different genotypes, we grouped CC genotype group(44examples), CT genotype group(262examples), TT genotype group(116examples).Reselt:1. We compared the difference of general information between CHD group and the control group. The difference of SBP, TG, FBG, HDL-c, gender, T2DM, smoking history was statistically significant (p<0.05).2. The frequency of CT genotype is the most. The difference of the frequency of3genotypes between CHD group and the control group and women’s two groups was statistically significant (p<0.05). The difference of the frequency of C or T allele was not statistically significant (p>0.05). The difference in men was not statistically significant (p>0.05).3. We compared general information between three PPARγC161T genotypes. The difference between CC genotype group, TT genotype group and CT group was not statistically significant (p>0.05).4. We compared the difference of the frequency of three genotypes between SAP group, UAP group, and AMI group. The difference was statistically significantly (p<0.05). But not between groups of the number of coronary artery stenosis (p>0.05). The frequency of CC genotype in D group between groups of Gensini score was most, the differerce of the frequency of three gentypes was statistically significant (p<0.05).The difference of the frequency of C or T allele was not statistically significant (p>0.05).5. An unconditional logistic regession analysis was applied. The result indicated that SBP, FBG, with T2DM, HDL-c, T allele carrier were statistically significant (p<0.05,p<0.05). It showed that high level of SBP and T2DM may be risk factors of CHD. T alle carrier and HDL-c may be protect factors of CHD.Conclusion:1. The frequency of three genotypes between CHD group and normal group was significant, which showed that there may be correlation between PPARγC161T gene polymorphism and CHD in Tianjin.2. The difference of the frequency of three genotypes between normal group, SAP group, UAP group, and AMI group was statistically significantly, which showed that PPARγC161T gene polymorphism may be related to different clinical types of CHD.3. The difference of the frequency of three genotypes between different degree groups of coronary artery stenosis was statistically significantly, which showed that PPARγC161T gene polymorphism may be related to coronary artery stenosis degree.4. Single factor regression analysis showed that T allele was the protective factor of CHD. The risk in T allele carrier was lower than those with CC genotype. The protective effect was more obvious in those with CT genotype. Multiple regression analysis showed that CT+TT was independent protective factor CHD.