Relationship Between Inflammatory Factor And Cognitive Function In Metabolic Syndrome Patients

Objective:The aim of this study as follows:firstly, analyzing cognitive of patients of metabolic syndrome in Tianjin; then exploring the relationship between metabolic syndrome and cognitive in patients; and studying inflammatory factor and cognitive impairment.Methods; Patient volunteers of this study came from Tianjin Medical University Metabolic Disease Hospital and Tianjin Huanhu Hospital. Study sample were170, general information, blood sample and clinic data were collected between June2012and October2012. Inflammatory factor was measured by test kit. Motreal cognitive assessment was used for cognitive assessment. In170patient volunteers, there were60patients of metabolic syndrome with mild cognitive impairment (MS/MCI), sixty were metabolic syndrome with normal cognitive (MS/NMCI), the other50patients were no metabolic syndrome with normal cognitive (NMS/NMCI). SPSS17.0software was used for data analysis. One way ANOVA analysis was used for means comparing in three groups, LSD method for differences analysis between two groups. Chi-square test was used for frequency analysis and logistic regression for risk factors analysis.Results:(1) There was no statistical difference in gender, age and education level within three groups (MS/MCI, MS/NMCI and NMS/NMCI).(2) Statistical differences were found in history of coronary heart disease, hyperlipidemia and other clinical date (P<0.05).(3) Statistical differences were found in scores of MoCA (F=99.98,P=0..00), visual spatial and executive function, attention, language, abstraction, delay recalled, orientation within three groups (P<0.05). There was no statistical difference in naming.(4) Statistical differences were found in scores of MMSE (F=361.39,P=0.00), executive function attention, calculation recall and language ability within three groups (P<0.05). There was no statistical difference in ability of memory.(5) Statistical differences were found in scores of ADL (F=21.30,P=0.00), group of MS/MCI had a highest score of ADL, group of NC had a lowest score of ADL. LSD method f found that there were statistical differences between group of NC and group of MS/NMCI, group of NC and group of MS/MCI, group of MS/NMCI and group of MS/MCI.(6) Statistical differences were found in hs-CRP (F=14.99, P=0.00), hs-CRP highest in group of MS/MCI and lowest in group of NC. LSD method f found that there were statistical differences between group of NC and group of MS/NMCI, group of NC and group of MS/MCI, group of MS/NMCI and group of MS/MCI.(7) Statistical differences were found in Tumor Necrosis Factor-a(F=11.03,P=0.00), tumor Necrosis Factor-a was highest in group of MS/MCI and lowest in group of NC. LSD method f found that there were statistical differences between group of NC and group of MS/NMCI, group of NC and group of MS/MCI, group of MS/NMCI and group of MS/MCI.(8) Logistic regression analysis result shows that leve of hypertension (OR=1.82,P=0.00), CVD (OR=2.78, P=0.02) and liver fat (OR=3.59, P=0.00) were risk factors of metabolic syndrome with mild cognitive impairment. Conclusion:We found that patients of metabolic syndrome with mild cognitive impairment (MS/MCI) had more serious inflammation than other groups. Inflammation could decrease cognitive function in patients of metabolic syndrome.