Analysis Of Prognosis And Influencing Factors Of246Uyghur Patients With Primary Hepatic Carcinoma In Xinjiang Region

Objective: To investigate the prognostic influencing factors and the effects of differenttreatments by analyzing Uyghur patients with primary hepatic carcinoma treated in ourhospital. Methods: We retrospectively analyzed the clinical data of246Uyghur patientswith PHC. Survival rate was calculated by Kaplan-Meier method，univariate analysis bylog-rank test was used to determine the prognostic influencing factors，multivariateanalysis by Cox proportional hazard model was used to determine the independent factorsof prognosis. Results: The median survival time of the246patients was10.7months. The1st、2nd、3rd、4th、5thsurvival rate were41.97%、22.13%、14.87%and8.92%respectively.The multivariate analysis indicated that the age(P=0.003), neoplasm staging (P=0.000),portal cancerous thrombus (P=0.000), Child-Pugh grading (P=0.000) and levels of serumLDH (P=0.000) were the independent prognostic factors. The median survival time ofpatients treated by surgery, TACE, chemoradiation or RFA was19.2months, whichwas only9.1months for the group of support therapy. The therapeutic efficacy ofcombined therapy was better than that of single therapy. The median survival time ofpatients treated by operation-primary-multi-therapy was64.9months. Conclusion: Theindependent factors of prognosis included age, neoplasm staging, portal cancerousthrombus, Child-Pugh grading and levels of serum LDH in Uyghur patients with primaryhepatic carcinoma. The therapeutic efficacy of surgery, TACE, chemoradiation and RFAwere significantly better than that of support therapy. The therapeutic efficacy ofcombined therapy was better than that of single therapy. Theoperation-primary-multi-therapy was the ideal treatment of PHC.