Dynamic Contrast-enhanced MR Imaging And Diffusion-weighted Imaging Of Breast Cancers: Correlation With Prognosis Factors Of Molecular Biology

Objective：To analyze the dynamic contrast-enhanced breast magnetic resonancescan (DCE-MRI) morphology hemodynamic parameters and apparent diffusion coefficient(ADC value) and the correlation between molecular biology to explore the in vivoassessment of prognosis of breast cancer possible.Methods：one hundred and four lesionsfrom one hundred and four patients with breast cancer underwent dynamiccontrast-enhanced MR imaging and diffusion-weighted imaging before operation.Themorphological characteristics on DCE-MRI， the type of time signal-intensitycurve(TIC),the early-enhancement rate,the differentiations of different ADC(b=500、1000s/mm2) were recorded.The correlation between them and detectedbiomarkers(ER,PR,c-erbB-2,Ki-67)were statistically analyzed with the Spearman RankCorrelation.Results：The ring-like enhancement correlated positively with the expressiondegree of Ki-67(r=0.276);the type of TIC correlated negatively with the expression degreeof PR(r=-0.295);the early enhancement rate correlated positively with the expressiondegree of c-erbB-2(r=0.273). The spicular enhancing periphery of the tumor, the internalhomogeneous, ADC value can not evaluate the prognosis of breast cancers in molecularbiology.Conclusion: Dynamic contrast-enhanced MR imaging play not only importantrole in the differential diagnosis of breast cancer, but also is indirectly helpful in vivo bothin evaluating the prognosis and in drawing up the treatment plan of the breastcarcinoma.The statistical significant correlation between morphological characteristics、some kinetic enhancing parameters on DCE-MRI and detected biomarkers wasfound.Ring-like enhancement,washing out TIC the early enhancement rate more than onehundred percent are suggestive of unhealthy prognostic factors.