Analyse Correlate Influence Factors For Severe Reflux Esophagitis

Objectives: To investigate risk factors for Severe reflux esophagitis by multivariateanalysis,including obesity and smoking and alcoholconsumption，hiatal hernia, blood lipid,blood glucose and fatty liveras covariates.Methods: A case—control study wasdesigned． Among62patients who accepted gastroseopie examination from Jan.2011toDec.2012．Those62patients with Severe reflux esophagitis were included in the casegroup，and62controls were selected from the same population by matching gender, ethnic,age(±2years) and endoscopic examination date. Control group was no explicit lesions(visual and pathological examination only mild chronic superficial gastritis) by endoscopy.We further measured their waist circumference,hip circumference, blood lipid, and fastingblood glucose. multivariate Logistic regression analysis was used to identify theindependent risk factors associated with the presence of Severe reflux esophagitis.Results:Severe Reflux esophagitis cases showed higher waist hip ratio(WHR) and hiatal herniaand smoking than those in controls(P <0.001). multivariate Logistic regression analysisdemonstrated that there was a positive dose-response relationship between Severe refluxesophagitis and waist hip ratio (P=0.001，OR=4.578，95％CI=1.875-11.174),hiatalhernia(P=0.001，OR=5.438，95％CI=1.871-15.802) and smoking(P=0.001，OR=2.923，95％CI=1.217-7.020).Conclusion: Central obesity，hiatal hernia and smoking increase therisk of erosive esophagitis. hiatal hernia is an important rease to generate Severe refluxesophagitis.