Clinical Analysis Of Metastatic Liver Cancer Cases With Transcatheter Arterial Chemoembolization

Objective:Metastatic liver cancer is one of the most common gastrointestinal malignancies. In recent years, the availability of measures have increased the rate of the early diagnosis and reduced the mortality of metastatic liver, such as the developing technique of early diagnose、the improving of the surgery and rationalization of the treatment. Surgical treatment is considered to be standard treatment of metastatic liver cancer.However, a large number of clinical cases and research data to confirm that metastatic liver cancer are often multiple metastases and more associated with lymph node metastasis or even around other distant organ metastasis at the same time. So, the therapeutic effect is not obvious by resect metastasis simplyWith the rapid development of modern medicine, especially the interventional radiology develop rapidly, treatment of the metastatic liver cancer has made positive progress. Transcatheter arterial chemoembolization is considered to be one of the most effective ways occupies an extremely important role in the comprehensive treatment in recent years. At present, scholars generally believe that a variety of factors associated with the efficacy of metastatic liver cancer cases with transcatheter arterial chemoembolization. We would give a research of metastatic liver cancer containing the clinical parameters (age, gender, source, distribution, multi-focal, primary tumor resection, extrahepatic metastasis), pathological parameters (histopathological grading), metastases blood supply, et al, and analysis the relative factors in metastatic liver cancer with transcatheter arterial chemoembolization. To analyze retrospectively the clinical information of102patients with metastatic liver cancer during5years in the Anhui Province Hospital of Anhui Medical University and the Third People’s Hospital of Hefei. To evaluate the related risk factors affecting prognosis and the relationship between various clinicopathologic factors.Methods:The clinicopathologic factors and outcomes of102patients with metastatic liver cancer from January2007to August2012in the Anhui Province Hospital of Anhui Medical University and the Third People’s Hospital of Hefei were reviewed and analyzed. An Excel database was built with clinical follow-up survey and analyze the prognostic factors of the metastatic liver cancer.SPPSS13.0software package was used. Multiple factors analysis were assessed by Cox proportional hazards regression model. Univariate analysis were assessed with x2test. A statistically significant difference was indicated by p<0.05.Results:1. Group of55patients with TACE include41male cases and11female cases. The average age was60.3years old (36-79years old). The median age was47years old. The peak focus on60-70. Control group of47patients with intravenous chemotherapy include28male cases and19female cases. The average age was58years old (37-80years old). The median age was59years old. The peak focus on60-70and40-50.2.0.5years,1,2year survival rates of TACE group were96.4%,60.0%,25.5%, and the median survival period was13months;0.5years,1,2year survival rates of control group were76.6%,40.4%,14.9%, and the median survival period was10months.3. There were11patients complete response and18partial response in the TACE group and total effective rate was52.7%. However, there were4patients complete response and11partial response in the control group and total effective rate was31.9%.4. Univariate analysis revealed that age, gender had no association with survival rates (P>0.05); source, distribution, multi-focal, Primary tumor resection, extrahepatic metastasis, histopathological grading and metastases blood supply was associated with patients’ prognosis (P><0.05).5. In multivariate analysis, pancreatic cancer, multi-focal, extrahepatic metastasis was the independent prognostic factor for patients with TACE (P<0.05), while other factors were not.Conclusions:1. Age, gender, source, distribution, multi-focal, Primary tumor resection, extrahepatic metastasis, histopathological grading, metastases blood supply was the significant prognostic factor for patients with TACE.2. Pancreatic cancer, multi-focal, extrahepatic metastasis was the independent predictor of outcome. Other treatments should be combined in order to achieve good treatments if somebody had these factors.3. The prognosis of metastatic liver cancer with TACE is closely related to clinic patho-logical features. We should assess systematicly prognostic correlative factors of metastatic liver cancer with TACE,work out a therapeutic schedule individually, to acquire well curative effect.