| objective:The purpose of this paper is to through the comparison Correlation between of the coronary heart disease risk factors and Serum apolipoprotein levels and the lesion counts and degree of lesions of coronary artery, Ascertain the meaning, For a better clinical diagnosis and treatment, provides the theory basis for prevention and treatment of the disease.Material and methods:Patients were randomly selected those were suspected with coronary heart disease and be checked by coronary angiography first time.862cases were selected. Before operation of Coronary angiography the5ml venous blood samples were be collected by vacuum blood coagulation test tube in the morning.The samples be tested by Clinical test center of own hospital.The concentration of TC,TG,HDL-C,LDL-C,apoA,apoB,BS etl. All test items accord with standard of laboratory quality control.All the patient voluntarily signed the Consent file before operation, In strict accordance with《the China percutaneous coronary artery intervention treatment guidelines (2011)》. the prepare were be done before operation. Coronary artery angiography be done accordance with the angiography American college cardiology(ACC) and The American heart association (AHA), Coronary artery angiography be done by normally seleceting the via radial artery pathway by Judkins, all operation by According to the standard position and add other position When it is necessary. The results of Coronary artery angiography be determined by experienced specialist of the Cardiac catheterization room. The standard of diagnosis of coronary heart disease:at lest there is a coronary artery or main branches of its narrows more than50%. The degree of stenosis be determined by Gensini score. All cases be divided into2groups:the group of coronary heart disease and the group of non coronary heart disease. The group of coronary heart disease be further divided by age into3groups:The group of youth, The group of middle-aged people, The group of the elderly. be divided by smoking into2groups:The group of smoking and the group of non smoking; be divided to2groups according to whether with hypertension (high blood pressure has not hierarchical):the group of high blood pressure, the group of non high blood pressure; be divided to2groups according to whether combined with diabetes in2groups: diabetic and non-diabetic group; be divided to3groups according to the numbers of the stenosis Coronary artery:one stenosis Coronary artery group,two stenosis Coronary artery group and three or more stenosis Coronary artery. be divided to4groups according to the degree of the stenosis Coronary artery:the first group of the Gensini score, the second group of the Gensini score, the third group of the Gensini score, the firth group of the Gensini score.All data using SPSS13.0statistical software package for data processing, measuring data to mean+/-standard deviation, said count data expressed as a percentage. Count data compared by chi-square test, measurement data to normality and homogeneity of variance test, measurement data comparing USES independent samples t test, more than two groups compare with single factor analysis of variance (one-way ANOVA), P<0.05as the difference was statistically significant.Results:Results:(1) Of862cases of coronary angiography positive case, hypertension, diabetes mellitus group, elderly group and obesity group,the lesions of coronary artery with three or more lesions is given priority,of the non hypertension group, non diabetes group, the young group, normal weight group,the pathological changes of coronary artery pathological changes is given priority to single lesion. the numbers of coronary artery lesion in Male and Female group without obvious difference;(2),862cases of coronary angiography positive cases, along with the level of total cholesterol (TC), low-density lipoprotein (LDL-C) in the serum, the coronary artery lesion counts and Gensini score increased significantly, and the degree of the coronary artery lesions was significantly positive correlation with them, the difference had obvious statistical significance; And varies with the level of high-density lipoprotein (HDL-C) in the serum, coronary artery lesion counts and Gensini score significantly are higher, high-density lipoprotein cholesterol (hdl-c) and coronary artery lesion severity was significantly negative correlation, the difference had obvious statistical significance; in the Serum the levels of triglyceride is no obvious correlation with the degree of coronary artery lesions, there was no obvious statistical significance difference.(3), Of862cases of coronary angiography positive cases, the level of serum apolipoprotein B (ApoB), ApoB/ApoA ratio was significantly positive correlation with degree of coronary artery lesions, differences have obvious statistical significance. There is no obvious correlation between serum levels of apolipoprotein A and degree of coronary artery lesions, there was no obvious statistical significance differenceConclusion:(1) hypertension group, diabetes group, elderly group, male, obesity group coronary pathological changes is given priority to with three or more lesions, showed that age, gender, weight, hypertension, diabetes is important risk for coronary heart disease.(2)In the serum total cholesterol, low density lipoprotein cholesterol and coronary artery lesion severity was significantly positive correlation, their are important risks factors of coronary heart disease (CHD), and serum levels of high-density lipoprotein (HDL-C) is negatively correlated to the degree of coronary artery lesions,it is a protective factor for coronary heart disease.(3) serum levels of apolipoprotein B, ApoB/ApoA ratio and degree of coronary artery lesions was significantly positive correlation, are important risk factors for coronary heart disease (CHD). |
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