Epidemiology And Clinical Features Of432Cases Of Patients With Hepatitis C Hospitalized In The First Affiliated Hospital Of Kunming Medical University From2009-2012

Background:The infection rate of HCV is about3%all over the worla, about170million people infect the HCV, and new infection is about3.15million every year. In our country, about40million people infect HCV, ordinary person anti-HCV positive rate is3.2%.Yunan intravenous drug addiction is serious,also is the hardest hit by HIV infection,and the HCV genotypes isolated in Yunan are complex,the prevalence of hepatitis C can not be ignored.It is easy to be chronicity after being infected, while,the treatment is long with expensive charge and poor efficacy. There is some guiding significance in reducing HCV incidenceand increasing it’s diagnosis, treatment and preventing to learn about HCV epidemiologic and clinical features.Purpose:Learn about the epidemiologic and clinical characters of HCV inpatients, to study HCV infection rate in this area further and to supply reference for making proper preventive strategy.Method:432HCV patients who were hospitalized in infectious department and gastroenterology department of the First Affiliated Hospital of Kunming Medical University from2009-2012were screened out,including3cases of acute hepatitis,247cases of chronic hepatitis(156cases mild,43cases moderate,48cases severe), 164cases of liver cirrhosis,13cases of primary liver cancer and5cases of fulminant hepatitis.A descriptive retrospective method of epidemiology is adopted to study the demographic characteristics, clinical manifestation and virology characteristics of these patients.Results:1. The average age of the study population was45.6±12.4years, minimum was4years old, maximum was82years old.Male and female ratio was2.4:1;89.6%of the patients were han nationnality and the others wereHui,Yi,Bai,Dai,Lahu,Miao,Naxi and Zhuang, the majority of the ethnic minorities was hui,accounted for4.9%;41.9%of the patients were farmers and30.6%of patients without work2.22.7%of the patients were co-infection with hepatitis B virus, including patients with HBsAg positive (54.1%), HBeAg positive patients (6.1%), HBV DNA positive patients accounted for11.2%(11/98) and illness are3. In all patients with hepatitis C,22.5%had a history of blood transfusion and adjuvant therapies treatment,5.3%patients with intravenous drug use, a few patients had a history of dialysis or tooth treatment or tattoo, tattoo eyeline, another51.4%of the patients didn’t find any history related to blood-borne diseases.4.400patients had the records of HCV RNA detection, positive rate was91%, the105copies/ml of HCV RNA loads were32.8%which were the largest percentage; With the increase of HCV RNA loads in patients, the value of ALT and AST in patients also showed a trend of rising.421patients had the records of anti HCV detection, anti HCV positive rate was99.0%.5. Among the population studied,13.0%of patients had diabete, in addition, there were a small number of patients with autoimmune diseases, such as hashimoto’s thyroiditis (1.2%)、primary drying syndrome (0.2%). In323patients detected the antibodies of AIH, LC1positive rate was the highest as0.9%, one or more item showing positive patients (1.9%),1of them has a history of interferon treatment in front of the detection; In340patients who accepted the detection of the autoimmune antibodies, ANA positive rate was the highest as10.9%, one or more item showing positive patients accounted for15%,12of them (23.5%) has a history of interferon treatment before the test.6. In total sample,30.3%of patients has a long history of drinking,93.1%were male. Value of ALT and AST in patients with alcoholism group were higher than abstainers group.Conclusion:Blood transfusion and blood product may be the major way of infecting HCV in these patients, the condition of HCV infected along with HBV is obvious, the patient’s serum ALT/AST shows upward tendency along with HCV RNA loading capacity addition in the body. There exist HCV/interferon-related extra hepatic manifestations and autoimmune antibodies in the patients studied. The intemperance is common and alcoholic liver disease occurrence rate is high.