The Correlative Research Between The Level Of Serum Interleukin-17and Prehypertension

Background Prehypertension is the early stage of hypertension and cardiovascular events associated with increased blood pressure, the prevalence of prehypertension is higher, which has a higher risk of evolving into hypertension and cardiovascular events in the future. A lot of research that shows, the prevalence of prehypertension associated with gender, age, education degree, working strength, smoking, drinking, too much salt, exercise frequency, etc. The age, smoking and drinking are the risk factors of prehypertension; but female, highly educated, frequent physical exercise are the protective factors of prehypertension. The recent research has shown that the prehypertension people has been chronic inflammatory response. The interleukin-17(IL-17) is a kind of inflammatory factors, some research showed that which plays an important role in hypertension and vascular damage of animals, as well as which has an independent correlation with human hypertension. The related research of prehypertension and inflammatory response mainly concentrated in high-sensitivity C-reactive protein(hs-CRP), IL-6and tumor necrosis factor-a(TNF-a). There’s no research between level of serum IL-17and prehypertension at present.Objective To understand the differences in demographic characteristics, life behavior of prehypertension and normal blood pressure people; To realize the relationship between the level of serum IL-17and prehypertension.Methods The survey was performed from may2011to may2012in Tianjin. Using random sampling method, the age from40-70of the non-hypertension population in six districts were selected. Collect the general date such as gender, age, education degree, jobs, smoking, drinking, salt consumption, exercise frequency, etc. All the participants were divided into prehypertension group and normotensive group according to hypertension guidelines of China in2010. Using enzyme linked immunosorbent assay(ELISA) test the level of serum IL-17. Exclusion criteria:(1) severe renal dysfunction and dyshepatia;(2) cerebrovascular disease:cerebral hemorrhage, cerebral infarction;(3) Recent acute injuries, infection, malignant tumor, tuberculosis, asthma, rheumatoid arthritis, systemic lupus erythematosus, multiple sclerosis, psoriasis and inflammatory bowel disease. All the data were analyzed by using the SPSS17.0software. In quantitative variable, conform to the normal distribution of data were presented as mean±SD, comparison between the two groups using Student t test; Non-normal distribution variables presented as median, comparison between the two groups using Mann-Whitney U test and more than two groups using Kruskal-Wallis H test. Classification variables presented as rat or constituent ratio, and comparison among groups using Chi-squared tests. Bivariate correlation analysis using the Spearman correlation analysis. Using Logistic regression analysis to analyze risk factors of prehypertension occurred. P values<0.05denote statistically significant differences.Results1. The study involved612prehypertension (male205, female407), the average age of57±6.8years old; and431normotensive (male69, female362), the average age of54±6.6years old. Using Logistic regression analysis model analysis showed that age in50-59years old and60-70years old, smoking, drinking are risk factors for prehypertension, the odds ratio (OR) respectively were1.57(95%CI:1.11-1.21),2.52(95%CI:1.73-3.65),1.93(95%CI:1.40-2.67),2.14(95%CI:1.60-2.87); Female, high school and technical secondary school, college degree or above and actively physical exercise are protection factors of prehypertension, the OR values respectively were0.38(95%CI:0.28-0.52),0.71(95%CI:0.53-0.95),0.68(95%CI:0.49-0.94),0.62(95%CI:0.42-0.91). Adjusting for risk factors such as BMI, TC, TG, HDL-c, FBG, UA, etc, the results showed that age in60-70years old, drinking are risk factors for prehypertension, the OR values respectively were2.27(95%CI:1.20-4.33),1.76(95%CI:1.12-2.78).2. The level of serum hs-CRP in prehypertension is higher than normotensive (1.30vs0.90, P<0.05), the multifactor Logistic regression analysis showed that:the level of serum hs-CRP is independent risk factors of prehypertension (P<0.05, OR=2.13,95%CI:1.35-3.38).3. Selecting196cases of prehypertension people (male57cases, female139cases, the average age of57±6.6years) and198cases of normotensive (male27cases, female171cases, the average age of54±6.3years) to test the level of serum IL-17. The level of serum IL-17in prehypertension is higher than normotensive (7.00vs5.10, P<0.05); Single-factor Logistic regression analysis results showed that the serum level of IL-17is a risk factor of prehypertension, the OR value is1.50(95%CI:1.01-2.34); Using the multi-factor Logistic regression analysis model, adjusted for age, body mass index, FBG, UA and other risk factors, the level of serum IL-17remained a risk factor of prehypertension, the OR value is1.40(95%CI:1.15-1.72).4. Blood pressure from90/60mmHg to139/89mmHg, the level of serum IL-17is increasing accompany by a rise in systolic blood pressure of20mmHg and diastolic blood pressure of10mmHg (4.80vs5.40vs7.00;5.35vs5.85vs7.00, P<0.05).5. The serum level of IL-17and hs-CRP levels were positively correlated, the rs=0.311(P<0.01).Conclusion1. Age, smoking, drinking are risk factors of prehypertension; but female, highly educated, frequent physical exercise are the protective factors of prehyper-tension.2. The level of serum hs-CRP in prehypertension is higher than normotensive, which is independent risk factor of prehypertension.3. The level of serum IL-17in prehypertension is higher than normotensive, which is independent risk factor of prehypertension.4.The level of serum IL-17has a weak positive correlated to the level of serum hs-CRP.