| Objective:Threatened pre term magnesium sulfate and dexamethasone treatment was observed after perinatal child outcome. Specific observations indicators: Apgar score, neonatal asphyxia, perinatal mortality in children, in order to seek to improve the treatment outcome in preterm children。The method:Yanbian University Hospital obstetric patients, collected between January1,2005birth maternal580cases of pregnancy30～35, average age:30±2.6, primiparae:335, multiparous245cases。according to the situation of pregnant women on admission grouping will inevitably admission or premature termination of pregnancy due to pathological conditions of pregnant women must be set to the control group A, the situation threatened premature admission may occur after a certain time of treatment, such as tire premature rupture of membranes or irregular contractions occur and the line miscarriage and other patients to the treatment group B。According to maternal gestational different, will be divided into30to32+6maternal weeks group C group and33to35weeks group D, will be further divided into two groups of maternal magnesium sulfate and dexamethasone treatment group C1and D1group group and non-intervention control group C2group and D2group。Treatment group, according to the different time of termination of pregnancy, can be divided into treatment time≤2day group C1a group and D1a group and treatment duration>2days group C1b group and D1b group。Collected580cases of patients, including patients suffering from hypertensive disorders in pregnancy:111cases, further grouping of these patients will be admitted to hospital in critical condition when to terminate pregnancy in patients as the control group E, will be carried out hypertensive disorders in pregnancy in patients given standard treatment for the treatment group F group, but also according to the time of termination of pregnancy in patients with gestational age were divided into gestational age of30to32+6weeks group M and gestational age at33～35weeks group N group, and continued into control group (M2group and N2group) and treatment group M1group and N1group, in the treatment group, according to the termination of pregnancy at different times, can be divided into the treatment time≤2days group M1a group and N1a group and treatment time>2days group M1b group and N1b group。Collection of all pregnant women are single tires, each group of maternal age, parity and gestational age difference was not statistically significant。Clinical data of580patients were analyzed retrospectively to observe premature Apgar score, incidence of neonatal asphyxia, perinatal death rate, etc., is analyzed by using statistical methods, observation affect the prognosis of premature infantS。Result:(1)We compare group A and group B, found that combined use of sulfuric acid and dexamethasone treatment:treatment group B group and control group in A group in the incidence of neonatal asphyxia and perinatal death rate, P<0.05, the difference was statistically significant;(2)C1group and treatment group in different gestational age group and control group C2。D1and D2group in the incidence of neonatal asphyxia and perinatal death rate comparison, all P<0.05, the difference was statistically significant(3)Same gestational age different treatment time, finally ending in on perinatals effect is different, treatment time is2days or less C1n group and treatment of C1b>2days after comparison found that the incidence of neonatal asphyxia and perinatal death were significantly reduced. Same way Dla and Dlb group comparison, found that the incidence of neonatal asphyxia and perinatal death rate also is markedly reduced, all P<0.05, the difference was statisticall y significant;(4) In patients with gestational hypertension disease of premature, the treatment group than the control group the perinatal prognosis condition improved significantly. For M1and M2, N1and N2were found after comparison, the same gestational age, the treatment group in neonatal asphyxia rate and perinatal mortality rate than the control group decreased obviously. Same gestational age, between battle and M,h, N1a and N1b group compare, battle and N1a group’s incidence of neonatal asphyxia and perinatal death rate decreased significantly, P<0.05, the difference has statistical significance;Conclusions:(1)For pregnant women, preterm labor, early intervention dexamethasone, and magnesium sulfate, significantly reduced the incidence of perinatal asphyxia and child mortality; and with the extension of therapeutic intervention, the prognosis of perinatal child has been significantly improved;(2)For pregnant women with hypertensive disorders in pregnancy, early application of therapeutic interventions compared with untreated patients, survival was significantly higher perinatal children;(3)Magnesium sulfate in the inhibitory effect of contractions, spasmolysis, also has effect for the prognosis of premature infants;... |
PDF Full Text Request