Differential Expression Of VEGF In Patients With Benign And Malignant Pleural Effusions

ObjectiveTo discuss the expression differences of Vascular endothelial growth factor (VEGF) between tuberculosis pleurisy and malignant pleural effusions through detecting the VEGF content in pleural fluid and serum.To analyse the correlation of the presence of VEGF in different cause pleuritis pleural fluid and serum.MethodsChoose thirty patients with tuberculosis pleurisy and thirty patients with malignant pleural effusion as objects. Those patients were confirmed by pathology through thoracoscope. Take patient’s10ml hydrothorax and5ml blood on the same day. Used double antibody sandwich enzyme-linked immunosorbent assay (ELISA) to detect the level of VEGF in pleural effusion and serum. We analyzed the data through T test and used linear correlation and stepwise regression analysis to analyse the correlation.ResultsThe average level of VEGF is45.33±18.33pg/mL in serum and62.73±24.65pg/mL in pleural fluid in the TB group. The average level of VEGF is66.00±29.83pg/mL in serum and95.54±42.11pg/mL in pleural fluid in the malignant group. The level of VEGF in pleural fluid was higher than that in serum in both tuberculosis group and malignant group (t=2.61,3.315, P<0.05). Comparing the value of VEGF in the serum and pleural fluid between the two groups, it had significant difference (t=3.9,5.2, P<0.05). The level of VEGF in serum and pleural effusion were positively correlated in the two groups (R=0.53,0.38,P<0.05).ConclusionVEGF has expression differences between tuberculosis pleurisy and malignant pleural effusions. The VEGF of malignant group was higher than that of TB group both in pleural fluid and serum. The level of VEGF in pleural fluid was higher than that in blood in the two groups. The detection of VEGF has value in diagnosis and differential diagnosis between tuberculosis and malignant pleural effusions.