Comparative Analysis Of Clinical Materials Among385Postoperative Thyroid Benign And Malignant Nodules Patients

Objective: To analyse the clinical materials of385postoperative thyroid nodulespatients, and to compare the correlation affected by different factors between benignand malignant thyroid nodules.Methods: This retrospective study included385patients after thyroid operation ingeneral surgery department of our hospital. We analysed age, gender, height, bodyweight, uric acid, blood glucose, thyroid function, ultrasonic scanning of thyroid andpathological results between benign and malignant thyroid nodules group, and thenmade comparative analyses between the two groups.Results:1. There were264benign nodules (68.57%) and121malignant nodules(31.43%) among385cases. The average age of benign nodules group was (48.06±13.37)years old, while malignant nodules group was (45.63±12.51) years old. Comparing theproportion of benign nodules and malignant nodules in different age group, at the age of20to69years old, the lower the age, the higher the ratio of thyroid cancer.2.No difference was found in men and women between benign and malignantnodules group (P>0.05).3. According to body mass index (BMI), the ratio of malignant nodules group wasthe highest in overweight group, and the higher in obesity group.4.The level of fasting blood glucose in the benign nodules group is (5.61±1.07)mmol/L, the malignant nodules group (5.86±1.21) mmol/L. The level of fasting bloodglucose in the malignant nodules group was significantly higher than that in the benignnodules group (P<0.05).5. The level of thyroid-stimulating hormone (TSH) in benign nodules group is(1.62±1.3) uIU/ml, while the malignant nodules group (2.02±2.59) uIU/ml，The levelof TSH in malignant nodules group is significantly higher than that in the benignnodules group (P<0.05). 6. There was no difference in the level of blood uric acid, free thyroxine and freetri-iodothyronine between benign and malignant nodules group (P>0.05).7.The patients were grouped into HT group and non-HT group accord topostoperative pathology results.Compared the incidence of thyroid carcinoma, theincidence was higher in HT group than in non-HT group.8. The ratio of irregular, unclear boundary, with calcification and lymph nodemetastasis in the malignant nodules group was significantly higher than that in thebenign nodules group through ultrasonic scanning (P<0.05).9. Logistic regression analysis revealed that the existence of thyroid cancer wassignificantly associated with age, fasting blood glucose, ultrasonic informations (lymphnode metastasis, irregular and with calcification).Conclusions:1. The levels of the blood glucose and thyroid-stimulating hormonein the malignant nodules group are higher than that in the benign nodules group.2.Compared the incidence of thyroid carcinoma, the incidence was higher in HTgroup than in non-HT group.3. There exists a negative correlation between age and thyroid cancer. the lower theage, the higher the proportion of thyroid cancer.4.Early age, blood glucose and thyroid-stimulating hormone might be risk factorsfor the development of thyroid cancer. Some ultrasonic informations (lymph nodemetastasis, irregular and with calcification) suggest the possibility of thyroid cancer.