Analysis Of Hospital Infection Pathogenic Bacteria And Drug Resistance In Weihai City

Objective:With the widespread use of the broad-spectrum expansion of rawpigment，invasive operation，increase in people who have low immune function，infectious diseases of the hospital bacterial spectrum also changed，resistant bacterialand fungal isolation rate also increased，become important pathogens of nosocomialinfection.The consequences of hospital infections not only increase the patient’shospital stay，aggravate the condition，also increase the economic burden of patients，society， hospital， especially for patients having a negative impact. So，studyingon hospital pathogens distribution and age changes are very important and practicalsignificance for the prevention and control of hospital infections，improving patients’quality of life，enhancement of the patient’s physical health，shorterning hospitalstays，reducing the financial burden of patients.The main objective of this study is toexplore the hospital infection characteristics and resistance to changes in pathogendistribution to provide a reference for the clinical use of antibiotics and increasementawareness of the clinical doctor.Methods:A retrospective survey methodology was used.A total of1775infected cases of hospitals with various types of clinical specimens of patients withcensorship was randomly selected from three Weihai hospitals during2006-2010.National Clinical Laboratory Procedures， vaccination， isolation， culture，theSiemens DADE BEHRING WA40S1isolates were identified. The bacteria wereisolated and cultured in accordance with the American Society for ClinicalLaboratory Standards Board (NCCLS) guidance principle.Bacterial culture mediumM-H agar medium， all strains use the Behring MicroScanauto SCAN4microorganisms automatic analyzers for bacterial identification. Susceptibilitytesting with twice the range of dilution method. Fungi submission of specimens, vaccination, isolation, cultivation, identification and drug susceptibility testing,Application the Zhuhai dark horse Bioengineering Co., Ltd. production bymicroorganisms room according to the National Clinical Laboratory Procedures"Bact-microbial analysis of the IST and supporting the identification card,completionof the drug Unscented.Results:1145pathogens was found from1285specimens， the positive rateis89.11%.435gram-negative bacteria， accounting for38.01%；383gram-positivebacteria， accounting for33.4%； fungi327， accounting for28.55%. The mainstrains of Candida albicans (12.14%)， Escherichia coli (11.10%)， Enterococcusfaecalis (12.05%)， Pseudomonas aeruginosa (7.17%)， Klebsiella pneumoniae(4.90%)； The isolation rate of E. coli showed a decreasing trend (13.95%in2006to8.67%in2007to8.81%in2008，200912.27%201012.06%)， Pseudomonasaeruginosa and separation rates have increased year by year phenomena (20063.10%20075.10%20086.17%20099.39%20108.89%)； fungal detection rate isrelatively stable for five years (200623.26%200729.08%200829.52%200929.60%，28.57%in2010). Imipenem was Escherichia coli， Enterobacter cloacae，Acinetobacter bacilli sensitivity antimicrobial agents； P. aeruginosa resistance ratesto erythromycin， ciprofloxacin， imipenem； Klebsiella pneumoniae to imipenem，ampicillin resistance is low； Enterococcus faecalis， aztreonam， ampicillinresistance rates， the lowest resistance rates of Staphylococcus aureus tociprofloxacin.5-fluorocytosine and amphotericin B is the highest level of drugsensitivity of Candida yeast.Conclusion: Hospital infection of pathogens are most of the opportunisticpathogen. Different years， different hospitals of clinical infection types ofpathogens， constitute different； strengthen hospital infection cases bacteriologicalmonitoring and dynamic analysis， combined with the sensitivity test results,areasonable choice of antibacterial drugsright to carry out the study of InfectiousDiseases to develop effective infection control measures to prevent infectionoutbreak.