The Circulating Plasma Copeptin In Patients With Acute Coronary Syndrome And Its Clinical Implication

Objective: Explore the level of Copeptin with acute coronary syndrome(ACS),coronary artery disease severity and coronary heart disease risk factors in humanplasma.Method: Totally consecutive96hospitalized patients (49male and47female)whowere suspected as having coronary heart disease(CHD) and acute coronarysyndrome(ACS),exclude abnormal glucose tolerance, pregnancy, liver or renalinsufficiency, infection, malignant tumor, after coronary artery bypass surgery(CABG)or precutaneous coronary intervention(PCI) etc. The ACS patients were further dividedinto subgroups according to the number of diseased coronary branches and Gensini’sscore. Fasting plasma glucose (FPG), fasting insulin (FINS), blood fat and bloodpressure, height, body mass index were measured,and age,sex and prior medicalhistories including hypertension,diabetes mellitus and smoking status were obtainedbefore CABG in all patients.Copeptin were compared statistically between thesubgroups and correlation coefficient of copeptin and other conventional risk factors forCHD was calculated.Measurement data which follows the normal distribution weredescribed with mean±std and T-test was used to compare the difference between twogroups and the difference among three or more groups were compared with ANOVA.Inaddition,the Pearson method was also employed for the correlation analysis.Thedifference between enumeration data were compared with Chi-square test.All the datawere analyzed by SAS17.0and P＜0.05was supposed to be statistically significant.Result:1.Plasma copeptin in ACS patients was significantly higher than that incontrol(P＜0.05); Plasma copeptin in AMI patients was significantly higher than that inUA.2.Plasma copeptin in double diseased coronary branches subgroup and threediseased coronary branches subgroup was respective significantly higher than incontrols an single diseased coronary branche subgroup(P＜0.05),but plasma copeptin in double diseased coronary branches subgroup and three diseasedcoronary branchessubgroup have no significant statistical difference (P＞0.05).Plasma copeptin in20≤Gensini’s score＜40subgroup and Gensini’s score≥40subgroup was respectivesignificantly higher than that in controls and0＜Gensini’s score＜20subgroup(P＜0.05),but plasma copeptin in20≤Gensini’s score＜40subgroup and Gensini’s score≥40subgroup have no significant statistical difference (P=0.125).Conclusion:1.Acute coronary syndrome patients with copeptin levels weresignificantly increased, suggesting that the level of plasma copeptin was positivelycorrelated.2.Especially in double diseased coronary branches subgroup,three diseasedcoronary branches subgroup,20≤Gensini’s score＜40subgroup and Gensini’s score≥40subgroup,which indicate that plasma copeptin level within a certain range can beused as a parameter to predict pathological severity of coronary atherosclerosis, But forthe identification of severe coronary lesions has little significance.3.Plasma copeptin is not correlated with age, body mass index,hypertension,bloodpressure,smokingstatus,diabetes mellitus, TG, TC, LDL-C, HDL-C and FPG.