A Study Of Relationship Between Brain Functional Connection Using Resting State FMRI And Memory Impairment Using Neuropsychological Tests In Temporal Lobe Epilepsy

ObjectAnalysis the relationship between brain functional connection using resting statefMRI and memory impairment using neuropsychological tests in patients withtemporal lobe epilepsy to explore the features of connectivity of rest-fMRI inpatients with temporal lobe epilepsy and its value in evaluating the memoryimpairment.MethodsCollect16patients from Fujian Medical University Affiliated Union Hospitaloutpatient and inpatient department from January2012to March2013, diagnosisedas non-focal temporal lobe epilepsy after clinical onset, EEG an MRI evaluation,with an average age of23.75±1.47year-old, of which11were male and5females.The rest-fMRI examination performed in all patients, choose bilateral hippocampalseed point, get the diagram of connection between bilateral hippocampal and wholebrain,and meanwhile evaluate the memory function by neuropsychological-scalememory function test..Also choose the healthy controls whose age,gender,educationare matched the above patients. Compare the values between patients and controls toexplore the features of connectivity of rest-fMRI in patients with temporal lobeepilepsy and its value in evaluating the memory impairment.Results1. The scores of memory quotient, point to memory, associative learning, the imagefree recall, recognition of nonsense figure, portrait characteristic Contact recalls inpatients with temporal lobe epilepsy were lower than the normal control group. 2.The higher connectivity brain regions of bilateral hippocampus with whole brain inpatients with temporal lobe epilepsy than the normal control group are leftparacentral lobule, the left precentral gyrus, the left postcentral gyrus, left premotorcortex and supplementary motor area,the left medial frontal brain regions and so on;3. The lower connectivity brain regions of bilateral hippocampus with whole brain inpatients with temporal lobe epilepsy than the normal control group are the rightcerebellum, the left superior temporal gyrus and so on;4. The damage of default network in patients with temporal lobe epilepsy is notbovious;5.The positively correlational brains between the connection in patients with temporallobe epilepsy and memory quotient are bilateral anterior cingulate gyrus, bilateralprecuneus/posterior cingulate and so on.6.The negatively correlational brains between the connection in patients withtemporal lobe epilepsy and memory quotient are the left inferior frontal gyrus, leftpostcentral gyrus and so on.Conclusions1. The memory function of patients with temporal lobe epilepsy are Impaired.2.The left paracentral lobule, left precentral gyrus, left postcentral gyrus, left premotorcortex and supplementary motor area, left medial frontal brain areas may constituteepilepsy network in patients with temporal lobe epilepsy,play an important role indevelopment process of epilepsy.3. The function abnormalities of The right cerebellum, left superior temporal gyrusmay be related to cognitive impairment in patients with temporal lobe epilepsy4.Bilateral anterior cingulate gyrus, bilateral precuneus/posterior cingulate, leftinferior frontal gyrus, left postcentral gyrus has potential clinical value to predict thememory function by strength functional connectivity between the bilateral hippocampus and whole brains.