Effects Of Sufentanil Combined With Dexmedetomidine On Postoperative Analgesia In Children Undergoing Tonsillectomy

Objective: To observe the effect of sufentanil combined withdexmedetomidine on Patient-controlled analgesia in children undergoingtonsillectomy.Methods: Eighty children with ASA physical status I or II undergoing elective tonsillectomy were randomly divided into four groups（S,SD1,SD2,SD3） with20each: group S received sufentanil0.04ug.kg^-1.h^-1, groupSD1received sufentanil0.03ug.kg^-1.h^-1+dexmedetomidine0.03ug.kg^-1.h^-1, groupSD2received sufentanil0.03ug.kg^-1.h^-1+dexmedetomidine0.04ug.kg^-1.h^-1, groupSD2received sufentanil0.03ug.kg^-1.h^-1+dexmedetomidine0.05ug.kg^-1.h^-1. ThePatient-Controlled Analgesia pump was set in all children as follow: a initial dose0ml,continuous perfusion rate2ml/h, single bolus2ml, lockout time15min, totalvolume100ml. Faces pain scale（FPS） and Ramsay sedation scale were recorded at30min，1h,2h,4h,12h,24h and48h postoperatively. The number ofpatient-controlled press of the pump and the incidence of side effects wererecorded.Results: FPS of the four groups unless group SD1at all the time points wereless than4. Compared with group S, group SD1had higher FPS scores at2h,4hpostoperatively （p<0.05）,group SD2,SD3had lower FPS scores at4h,12hpostoperatively（p<0.05）. Compared with group S, group SD3had higher Ramsayscores at2h,4h postoperatively（p<0.05）.The number of self-controlled press of thepump in group SD1was markedly more than other groups （p<0.05）. Theincidence of nausea and vomiting in group S was higher than groups SD2,SD3（p<0.05）. Conclusion: Dexmedetomidine can reduce postoperative consumption ofsufentanil in Children undergoing tonsillectomy, decrease the incidence of nausea andvomiting and sustain an stable hemodynamics. The recommended dose ofdexmedetomidine is0.04ug.kg^-1.h^-1.