Safety And Clinical Effect Of A Compound Praziquantel Piece In The DOG

Oxibendazole to azole in the TIMA clinical recognized as a drug of anti-intestinal nematodes. Cattle, sheep, dogs, cats and mice, numerous studies showed Oxibendazole secondary infection of nematodes, better insecticidal effect. Praziquantel is a broad-spectrum anti-schistosome, tapeworm medicine, has a broad spectrum of insect-resistant, good efficacy, easy to use, short course, and only appear when using high dose side effects and other advantages. Is TIMA clinical anti-people and livestock schistosomiasis drug of choice. At present, the mechanism of action of these two drug resistance mechanisms, structure-activity relationship and pharmacokinetic characteristics gradually been recognized, making a broader application prospects of these drugs. However, with the rapid development of the pharmaceutical industry, the pet industry in China has been an unprecedented development, large and small pet hospitals and animal pharmaceutical companies have mushroomed rise. With the hair is from clinical cases of gastrointestinal parasites appeared in large numbers, a few years ago for clinical pets anthelmintic small number of single role; pet-specific drugs gradually occupied the drug market, and how to evaluate the safety of the drug the effectiveness of the veterinary staff presented new challenges.Experiment1:The test according to the Ministry of Agriculture,1425Notice Pet drug target animal safety test guidelines as the basis to evaluate the clinical safety of the compound praziquantel tablets on the dogs. Test select24healthy adult dogs, male and female, were randomly divided into four groups, each group of six, according to the recommended clinical dose of the drug (10kg weight1), respectively, set the blank control group (10kg weight0films), clinical recommended therapeutic dose (10kg weight1), three times the clinical treatment dose group (10kg weight3), five times the clinical treatment dose group (10kg weight5). Once a day for consecutive3d, the trial period close observation of clinical symptoms in all dogs before the test by comparing in each group1 day,3days after administration, and3days after administration of blood biochemical indicators and histopathological school change, evaluate the clinical safety of the compound praziquantel tablets dogs. The results showed that:the difference between the clinical recommended therapeutic dose group, three times the clinical treatment dose group and five times the clinical treatment dose group and control group was not significant (P>0.05).Experiment2:The test according to the Ministry of Agriculture, No.1425Notice "pet anti-worm drug efficacy evaluation trials technical guidance principles" as the basis to evaluate the efficacy of the compound under artificial infection with praziquantel. Test selected24healthy adult dogs, male and female, were randomly divided into four groups, n=6, Toxocara eggs artificially infected with the canine, according to the recommended clinical dose of the drug (10kg weight1) based, respectively, to set the blank control group (10kg weight0), the clinical recommended therapeutic dose (10kg weight1), the clinical treatment dose reduced by half (20kg weight1), the clinical treatment of double dose group (10kg weight2tablets). Once a day for consecutive1d, during the trial closely observed clinical symptoms of each dog, three days prior to administration, the administration of the day (0d, before administration) and after administration of7,14,28,35,49d faeces were collected each dog, uniformly mixed stool samples, weighed3grams of feces into suitable containers, McMaster eggs counting method to evaluate the test efficacy. The results showed that:the clinical recommended therapeutic dose group, the clinical treatment of the half dose group and the clinical treatment of double dose group showed a good therapeutic effect.Experiment3:The test according to the Ministry of Agriculture, No.1425Notice "pet anti-worm drug efficacy evaluation trials technical guidance principles" as the basis to evaluate the natural infection case the efficacy of the compound praziquantel. Three pet hospitals in Nanjing selected80cases of dogs suffering from gastrointestinal parasite infections were randomly divided into experimental group (50cases) and control group (30cases) by age, breed, condition similar to the principle of the experimental group with the compound praziquantel tablets in the control group Nordson (fenbendazole). By observing changes in dogs, clinical symptoms, syndromes, and adverse reactions and to evaluate the efficacy of the compound praziquantel tablets. The results showed that the compound praziquantel tablets and the Nordson treatment of natural infection of gastrointestinal parasite infection efficacy between the total effective rate was no significant difference, and take into account when N greater the difference between the groups also the smaller and other factors, and in accordance with the basic principles of clinical pharmacists textbook "Therapeutics" as described in drug treatment, concluded that the compound praziquantel tablets for the treatment of clinical gastrointestinal parasitic infections, and its The recommended dose is reasonable.