| It is easy to modify the structure of nitrogen heterocyclic compounds and introduce functional groups. Nitrogen heterocyclic compounds own distinctive biological activity and pharmacological activity and are always used as structural units of pesticides and pharmaceuticals. For example,5-fluorouracil in this thesis, which is a typical anticancer active nitrogen heterocyclic compound, was connected to DTPA after structural modification. Then, its paramagnetic metal complexes were synthesized and studied as magnetic resonance imaging contrast agents, which may make contribution to the medical field. On the other hand, the nitrogen atom of the nitrogen heterocyclic compounds can coordinate to metal ions and form rich and distinctive complexes. Again in this thesis, acetyl pyrazine, as a two nitrogen atom containing heterocyclic compound, was used to synthesize a ligand which is easy to coordinate to metal ions. The fluorescent character of its complex was used to distinguish metal ions and act as a fluorescent probe.The work of this thesis includes two parts. One part is the synthesis of two ligands and their paramagnetic metal complexes as magnetic resonance imaging contrast agents. The two ligands are N1, N7-di(5’-fluorouracil-1’-acety1)aminoethyleneaminocarboxymethyl-diethylenetriamine-N1, N4, N7-triacetic acids (L1) and Diethylenetriamine-Nl, N7-bis(acetyl-nicotinohydrazide)-N1, N4, N7-triacetic acid (L2). Their GdⅢI), Mn(Ⅱ) complexes can be promising magnetic resonance imaging contrast agents because of good water solubility, high relaxivity and good imaging. Another part is the synthesis of two fluorescent probes for detecting aluminum ions. They are methyl pyrazinylketone benzoyl hydrazone (L3) and methyl pyridinylketone benzoyl hydrazone (L4). These two fluorescent probes own simple structure, high selectivity and low detection limit, and may accelerate the research work of aluminum fluorescent probes. |
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