One-Pot Three-Component Synthesis Of Imidazo[1,2-a]pyridine Derivatives

This thesis aims at the studies on the One-Pot Three-Component Synthesis of Imidazo[1,2-α]pyridine derivatives, meanwhile ferric chloride is used as catalyst in this process.The first part introduces the biological activity studies of imidazo[1,2-α]pyridine derivatives.The second part is about synthesis methods of the imidazo[1,2-α]pyridine derivatives. General synthetic route contains two types:the first one starts from the pyridine derivatives, the other is from the imidazole derivatives. In addition, we introduce simply the influence of synthesis reaction made by catalyst.The third part describes the three-component one-pot synthesis of imidazo[1,2-α]pyridine derivatives, ferrous chloride prepared by simple method is used as catalyst. All materials of the reaction are not only cheap, but also readily available. Moreover, the reaction condition is mild and the operation process is simple. The chemical structures of all products are obtained by measurements of400M NMR and high resolution mass spectrometry.