Design Of Theranostic Agents Based On Iron Containing Functional Nanomaterials

In recent years, the scientists had got wide and deep research in nanomaterials. Thedesign, preparation and application of nanomaterials gained much more attention of people.Theresearch showsthat nanomaterials have many special properties like quantum sizeeffect, Surface effect, small size effect, macroscopic quantum tunneling effect anddielectric confined effect. Therefore, nanomaterials are different from the bulk materials inmagnetism, electricity, mechanics, optics, thermology, chemistry, thus having a broadapplication prospect in some advanced areas such as magnetic materials, optoelectronicdevices, biological medicine, catalysis, aerospace, energy, environment and resources andso on.In the article, a series of nanostructures with uniform size were synthesized, Such asγ-Fe2O3nanoplate, Fe3O4cluster, Fe3O4@PDA-Au/Ag alloy nanobox and PDA-(α-FeOOH)composit materials. Through the testing methods likeFourier transform infrared (FTIR),Thermogravimetric analysis(TG), transmission electron microscope (TEM), X-raydiffractometer (XRD), X-rayphotoelectron spectra(XPS), high-resolution transmissionelectron microscopy (HRTEM), these materials were characterized in detail, and theresearch have been conducted on the relevant properties and application,the main taskinclude below aspects:1. By means of improved method, the iron oleate in special structure have beendeveloped and charactered. Compared iron oleate(1)’s molecular structure with normaliron oleate(2), preliminarily explore the mechanism that different molecular structure ofiron oleate lead to different iron oxide nanoparticle shape in the end. In this article, westudy the rule of mophology change of this material by alter the reaction condition, such astemperature and solvent, and attempt use different ligand with same method to developiron acetic, iron lauric and iron stearate.researching the mechanism of ultrathin γ-Fe2O3nanoplates by comparing the experiments.2. Different substance were observed in the surface betweenγ-Fe2O3and Fe3O4after characterising, and the substance that attach on the surface ofγ-Fe2O3can not be cleaned bythe normall method. In the experiment, by coating SiO2on the surface ofγ-Fe2O3byreverse microemulsion, and calcine, then remove SiO2, and we could get the cleanγ-Fe2O3nannoplates.3.Fe3O4cluster was prepared by solvothermal. A novel method to prepare Fe3O4-PDA/Ag core-shell and PDA/Ag microspheres was demonstrated. Moreover, the structurematerials of Fe3O4@PDA-Au/Ag alloy nanobox and PDA-Au/Ag alloy nanobox wasprepared by Galvanic Replacement Reactions between Ag and Au.4. Prepare PDA sphere, by the way of modifying the surface with poly(ethylene imine)(PEI), makes the surface take positive electricity, and Electrostatic assembled to make sureα-FeOOH nanoparticle absorb on the surface of PDA sphere, and PDA-(α-FeOOH)nanocomposite material was formed, which could have both of Photothermal therapy andcontrast agent property.