Pharmaceutical Grade Dextrose Monohydrate Production Technology

In this paper, based on starch as raw materials crystallized glucose technologyresearch, combined with biological enzyme technology innovation and progress, andion exchange, granular activated carbon bleaching and other new technologies, theemergence of new equipment, in-depth discussion and production crystalline anhydrousglucose combined primary crystallization, large-scale production of high-qualityinjection-grade dextrose monohydrate process design. Meanwhile, dextrosemonohydrate injection grade scale production of material balance, process control,parameter selection carried out detailed experiments to finalize the process route of theproduction process, the intermediate targets, procedures and methods.The preparation process of glucose experienced legal acid sugar, acid andenzymatic sugar sugar three phases double enzyme, the domestic preparation stage asugar water injection process selection generally have two kinds of primarycrystallization and recrystallization. The new design process route different from theprevious production process, centrifugal separation of the mother liquor not return a setof systems, using only high-purity refined sugar produced a cooling crystallizationdextrose monohydrate injection grade; once concentrated mother liquor alone, afterbleaching for crystallization and separation of mother liquor (second separationresulting mother liquor recapping used, some takeout) to produce raw material for wetcrystalline anhydrous glucose sugar. Because the production of injection grade dextrosemonohydrate process does not return with liquor, raw materials of high purity,crystalline amorphous good, fast, from the fundamental guarantee for the injection ofhigh quality sugar.Through the pilot, we identified an annual output of300,000tons injection gradedextrose monohydrate and13tons of anhydrous glucose routings and material balance,in the specific implementation of the project, in order to improve quality, reduceemissions, reduce costs, the starch hydrolysis process, we selected the U.S. highefficiency water heat injector, ensuring adequate gelatinized starch, and use the latesthigh-amylase and glucoamylase; in the ion exchange step we selected the U.S. Calgoncompany provides continuous ion exchange systems, in ensuring the effective removalof inorganic salts sugar solution, while the body of the pigment and organic proteinsplay a good removal function, and its use has greatly reduced the amount of acid;application of renewable utilization of granular activated carbon bleaching, evaporation temperature mechanical compression ensure the best quality sugar, dextrose injectionfor the production of high quality and lay a solid foundation.In this paper, dextrose monohydrate injection grade applications and theireconomic and social benefits were truthfully analysis, equipment investment,production and operating costs and other aspects of economic analysis and socialanalysis.Finally, dextrose monohydrate injection grade production test preparation andproduction process control, parameter settings strict rules and instructions, the existingproblems and improve the direction described.