Design And Sythesis Of Anticoagulant Macromolecule And Its Application As An Additive For Hemocompatibility Modification Of PES Membrane Surface

In this thesis, three sections were mainly involved. Firstly, APTTs of varied kinds of materials were studied, and the effects of material structure on APTTs were investigated. After that, based on the above results, three kinds of block copolymers were designed and synthesized, and its APTTs were also tested. Lastly, the block copolymer was used to modify PES membrane via liquid-liquid method. The structure and morphology of the modified membranes were characterized through FTIR and SEM; the APTT experiments were also tested. The following conclusions had been obtained, i) The hydrophilic materials, such as PVP, PEG and PHEMA, have a good anticoagulant property due to its perfect hydrophilicity; the ionic polymers, such as PSS, PMETA and PDMAPS, get high APTT because of both hydrophilic and ionic properties; the special structures of polysaccharides, such as Heparin and Chitosan, also contribute a lot to the excellent anticoagulant properties. According to the results mentioned above, three kinds of ionic block copolymers were designed and synthesized via RAFT method. Especially, some synthesized steps and some molecular structure revolutionary were included before obtain a kind of heparin-like block copolymers, the excellent anticoagulant properties of which comes from some synergy effects. The synthesized copolymer was further used as an additive to prepare PES membrane via liquid-liquid method. The prepared membranes, with regularly and smooth surface, have the average thick of about60microns. Based on speculation, the block copolymer immigrated and self-assembled before became as a real membrane, since the copolymer have the properties of hydrophiphilic character. The APTT was82s due to the5wt.%block copolymer adding. The perfect performance of the membrane make it has the possibility that it will be used in blood purity fields.