Studies On Asymmetric Mannich Reaction Ofα-phenylsulfonyl Phosphonates

In this dissertation, a series of thiourea catalysts based on the skeleton of the cinchona alkaloids were desigened, synthesized and applied to the Mannich reaction between N-alkoxycarbonyl aromatic aldehyde sulfones with a-phenylsulfonyl phosphonates to give β-amino phosphonate compounds. After optimization of the catalysts and the reaction conditions moderate yield (up to65%yield) and good enantio-selectivity (up to89%ee) were achieved when catalyst15was applied in the catalytic reaction. This catalytic system with good suitable for general substrates.